Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.1 (alkaline phosphatase)
 47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The histological and cytological features of follicular thyroid neoplasms with oxyphilic change (Hurthle cell tumors) may lead to the differential diagnosis of metastatic malignant melanoma. S-100 and HMB-45 staining was studied in 18 Hurthle cell tumors, 6 Hurthle cell carcinomas, and 5 cases of Hashimoto's thyroiditis using a rabbit polyclonal antibody to S-100 protein, a mouse monoclonal antibody to HMB-45 protein, and the avidin alkaline phosphatase method. All 6 carcinomas and 17 of 18 Hurthle cell tumors exhibited strong cytoplasmic and nuclear staining for S-100. One Hurthle cell carcinoma also contained a spindle cell anaplastic area that was negative for S-100. All cases of Hashimoto's thyroiditis displayed intense staining in Hurthle cells for S-100, with weak to negative staining in nonoxyphilic follicular epithelium. In the three studied lesions, all cases were negative for HMB-45 protein. Three nonthyroid oncocytic tumors (renal oncocytoma, oncocytic carcinoma of the parotid, and parathyroid oxyphilic adenoma) were found to be negative for both S-100 and HMB-45 staining. Hurthle cell lesions should be included in the differential diagnosis of S-100-positive tumors. HMB-45 remains a marker more restricted to melanocytic lesions.
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PMID:An immunohistochemical study of thyroid Hurthle cells and their neoplasms: the roles of S-100 and HMB-45 proteins. 793 16