Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.1 (alkaline phosphatase)
 47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There are several reports on the weak contractile activity of uterus in the prolonged pregnancy. Some investigations showed that the weak contractile activity is associated with the low contents of RNA, proteins and glycogen in the myometrial cell. The material was obtained from caesarean sections in 27 patients with prolonged pregnancy and 30 patients with normal pregnancy. It was found a diminished contents of glycogen and lipids in the myometrial cell, and a decreased activity of phosphorylase and alkaline phosphatase but an increased activity of acid phosphatase. The lower content of energetic material and changes in the activity of the enzymes shows that the metabolism of the myometrial cell is impaired in prolonged pregnancy. One can suppose that the lowered level of estrogens is responsible for the described changes. The lower level of estrogens probably causes the decrease of 3'5' AMP in the myometrial cell with the impaired cell metabolism as a consequence. This may be one of the causes of a weak uterine contractile activity in the prolonged pregnancy.
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PMID:[Histochemical studies of the myometrium in the prolonged pregnancy]. 121 Aug 81

Serum levels of alkaline phosphatase (AKP), heat stable alkaline phosphatase (HSAP), leucine aminopeptidase (LAP) and gamma-glutamyl transferase(gamma-GT) were determined in 249 blood samples from 202 women with normal or high-risk pregnancy at 30-42 weeks. The results showed that AKP and HSAP increased with the advance of gestational weeks (r = 0.9 259, P less than 0.01), reaching their plateau at 37-38th week. In severe hypertensive pregnant woman, AKP and gamma-GT were significantly elevated, while HSAP remained in consistent low level. A "dissociation phenomenon" between AKP and HSAP was discovered. In cases of prolonged pregnancy, oligohydramnios and IUGR with fetal distress and neonatal asphyxia, both AKP and HSAP were lower than those in normal pregnancies of same gestitional age. Serum level of HSAP might reflect the placental function, while combined with AKP and gamma-GT could also be helpful in assessing the severity of hypertension in pregnancy and in predictive feto-maternal prognosis.
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PMID:[Clinical significance of serum AKP, HSAP, LAP and gamma-GT determination in high-risk pregnancy]. 256 83