Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.1 (alkaline phosphatase)
 47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic hepatitis is defined as a condition in which liver injury tests (aminotransferases or cholestatic enzymes such as alkaline phosphatase) are abnormal on several occasions (usually determined monthly) for more than 6 months. The causes or the disease processes that can lead to chronic hepatitis are numerous, making the diagnosis and particularly the evaluation of patients with chronic hepatitis difficult or even mystical for those who do not identify themselves primarily as hepatologists. It is for these latter individuals (the bulk of practicing gastroenterologists and physicians in other primary fields) that the following editorial is written. It is hoped that a structured approach to the problem of chronic hepatitis will enable these physicians to make decisions concerning specific disease etiologies and, as a result, medical therapies for chronic hepatitis for their patients and that these decisions be both rational and simple. The system to be presented has been utilized by the author for over a decade and has been found to be very useful in training medical and surgical house officers as well as gastroenterology fellows and has been equally useful for the faculty of gastroenterology and hepatology programs. It is currently being used in Oklahoma at the Oklahoma Transplantation Institute and Hepatic and Digestive Diseases Center of Baptist Hospital in Oklahoma City.
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PMID:The ABCs of chronic hepatitis: reason out of confusion. 756 44

Ninety-seven bison (39 males and 58 females) were culled out during three successive winter seasons. No infection with BHV-1 and BHV-5 or other viruses was detected by PCR and SN methods. Advanced pathological lesions observed in males exhibiting symptoms of posthitis/balanoposthitis are probably due to secondary infection by microorganisms present in the prepuce (Corynebacterium spp., Bacillus spp., Fusobacterium necrophorum, Staphylococcus spp. (coagulase negative) and Staphylococcus hyicus). Histopathological examinations of sections from prepuce and lips of pudendum showed the presence of Onchocercinae nematode (Onchocerca sp.). A comparison of biochemical and morphological blood parameters in the bison with or without lesions in the digestive (presence of parasites), respiratory, urinary and reproductive tracts revealed that the most variable parameter during reproductive organ disorder is the leukocyte count, while disorders in the urinary and digestive tracts coincided with the age of animals. In cases of digestive disorder most changes were observed in the number of neutrophils and concentration of urea. The number of red blood cells, monocytes, the level of alkaline phosphatase (AP) and hematocrit negatively correlated with age. Negative correlation was also observed between the number of neutrophils, level of creatinine and lymphocyte proliferation index. However, positive correlation was seen between erythrocyte sedimentation rate (Spearman's correlation coefficient), level of alanine aminotransferase (ALT) and protein, and age of the bison. Positive correlation was also observed between the lymphocyte count and lymphocyte proliferation index. The attempt to determine the reference values for blood biochemical and morphological parameters showed similarities to those of cattle.
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PMID:Some morphological, biochemical and immunological blood parameters in European bison with or without lesions in the digestive, respiratory, urinary and reproductive tracts. 1793 85

Zinc deficiency, which is common in patients with cystic fibrosis (CF), can lead to several complications that may increase the number of hospital admissions in this group of patients. As supplementary zinc can prevent such complications, this study was performed to evaluate the effect of supplementary zinc on body mass index (BMI), forced expiratory volume in one second (FEV1) and number of hospitalizations in CF patients. In this study, 30 children with CF, who were referred to the Digestive Diseases Clinic of the Children's Medical Center in Tehran, were enrolled. Supplementary zinc of 2 mg/kg per day was administered to all patients. Serum level of zinc, alkaline phosphatase, and albumin as well as BMI, FEV1, and number of hospitalizations were compared before and after zinc administration. Height (p<0.001), weight (p<0.001) and BMI (p=0.001) were significantly increased after zinc, while the number of hospitalizations was significantly decreased (p=0.023). In contrast to patients with normal pulmonary function tests who received supplement therapy, BMI was not increased in those with abnormal pulmonary function after supplementary zinc. Supplementary zinc can increase BMI in CF patients, mostly in those with normal pulmonary function. While supplementary zinc may decrease the number of hospitalizations, other factors can also influence the hospitalization number.
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PMID:Effect of supplementary zinc on body mass index, pulmonary function and hospitalization in children with cystic fibrosis. 2491 44