Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.27.5 (RNase)
 17,967 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There was a significant reduction in body mass index (15%) and creatinine-height index (22%) in the chronic alcoholics with atrophic quadriceps biopsies indicating significant loss of skeletal muscle protein. Various parameters of nutrition were assessed in chronic alcoholics with and without the commonly associated selective atrophy of type II skeletal muscle fibres, to determine if malnutrition is related to the muscle injury. Serum alkaline ribonuclease activity, a marker of protein nutritional status, was significantly higher in chronic alcoholics compared to controls, suggesting some degree of overall protein malnutrition. However there was no significant difference in this enzyme activity between alcoholics with and without atrophic muscle biopsies. Deficiencies of one or more of thiamine, riboflavin, pyridoxine, Vitamin B12 and folate were found in half of the chronic alcoholics. There was no preponderance of such vitamin deficiencies among those patients with atrophic muscle biopsies. It is concluded that the quadriceps type II fibre atrophy is accompanied by a generalised decrease in skeletal muscle mass and that it is not primarily related to the patient's nutritional status.
 ...
PMID:Nutritional status in alcoholics with and without chronic skeletal muscle myopathy. 316 26

Mapped on the same chromosome as the Insulin-like Growth Factor II (IGF-II), an important factor regulating fetal growth, the H19 gene, is believed to play a role during embryogenesis and to share similar regulatory elements with IGF-II possibly by an enhancer competition system. This study was designed to characterize the ontogeny of H19 in sheep and the effect of maternal fasting on the expression of fetal IGF-II and H19 mRNA. A partial cDNA clone for the ovine H19 gene was isolated and used as a probe for RNase protection analysis. The ontogeny of H19 in liver, skeletal muscle and heart of ovine fetuses at 62,100 and 130 days, lambs at 1 month and adult sheep revealed high tissue levels of H19 mRNA during fetal life that decreased significantly after birth. Maternal fasting significantly decreased fetal liver H19 mRNA expression but did not alter fetal IGF-II mRNA expression. These results suggest that H19, like IGF-II, may play an important role in the regulation of fetal growth and define an environmental condition whereby these two genes are regulated independently.
 ...
PMID:Ontogeny of the H19 gene in sheep and effect of maternal fasting on its expression in the fetus. 1179 66