Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.27.4 (ribonuclease)
 6,621 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

When polyribosomal mRNP is exposed to ribonucleases most but not all of the mRNA is converted to acid soluble products. If mRNP is prepared under isotonic conditions there are two types of ribonuclease resistant core fractions, one which contains the poly(A) part of the mRNA and a second which contains mRNA fragments, 30-40 nucleotides in length. Like poly(A) these fragments appear to be protein associated in the mRNP complex. Non-poly(A) fragments in mRNP prepared from adenovirus-infected cells harvested in the late phase of infection contained only 3% of CAP structures and 12% of internally located methylated nucleotides. This indicates that no CAP structures but one out of the seven internally located methylated nucleotides found in the mRNA are situated in protein associated regions.
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PMID:Distribution of CAP and methylated nucleotides between the RNase sensitive and resistant fractions of mRNA in messenger ribonucleoprotein particles. 62 52

Prostate Cancer (CAP), is a complex disease with a multifactorial origin. It is characterized by heterogenous patterns of growth of neoplasic tissue, varying widely in its progression, age of beginning and therapy response. It is considered as the second most common cause of death by cancer in men and, it has been estimated, that one of five, suffers of CAP through the course of his life. The genetic etiology of neoplasic transformation of normal prostate cells is still not known; nevertheless, investigations in epidemiology have demonstrated a strong genetic component in its development, suggesting so much a pattern of mendelian inheritance as the presence of loci of susceptibility throughout the human genome. It has been described a cromosomic location related to the CAP in locus 1q24-25, denominated HPC1, where the gene RNASEL is located, and the seggregation of its alleles has been associated with the development of CAP in numerous familiar groups. The RNASEL gene codifies for a ribonuclease protein that degrades vi-ral and cellular ARN and takes part in the apoptosis. A decrease of the enzymatic activity up to three times in carriers of the G1385A polymorphism of this gene has been reported, and the same has been associated frequently with the development of CAP. Using a variant of the Polymerase Chain Reaction, Allele specific amplification, this investigation had as objective to determine the association between variant G1385A and CAP, in a sample of 103 masculine individuals with and without CAP, pertaining to the population of Maracaibo, Venezuela. An association between these variants and CAP could not be demonstrated.
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PMID:[G138A polymorphism of the RNASEL gene and its association with the development of prostate cancer. Preliminary study]. 1996 Oct 52