Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.27.1 (
RNase
)
16,360
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ca(2+) released from intracellular Ca(2+) stores is shown to be involved in pacemaker activity in the sino-atrial (SA)-node. However, little is known about the molecular identity of the Ca(2+) release channel/ryanodine receptor (RYR) involved in pacemaker activity. We examined the mRNA distribution of three different RYR isoforms (RYR1, RYR2, and
RYR3
) in the mouse SA-node.
RNase
protection assay and in situ hybridization revealed that RYR2 mRNA expresses widely in the heart including the SA-node, while
RYR3
mRNA expression is limited to the SA-node and to the right atrium. Thus, not only RYR2 but also
RYR3
may participate in pacemaker activity.
...
PMID:The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors. 1455 May 62
