Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.27.1 (
RNase
)
16,360
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin 11
(
IL-11
) is a multifunctional cytokine that has diverse effects on blood cells and their precursors and on a number of cell types outside of the hematopoietic system. The cDNAs encoding murine
IL-11
and its receptor alpha-chain (IL-11R alpha) have recently been isolated. We have used the
RNase
protection assay to examine the expression of murine
IL-11
and IL-11R alpha in a range of adult mouse tissues, in embryos, and during development of embryonic stem (ES) cells into cystic embryoid bodies in vitro. The testis showed a high level of
IL-11
gene expression while a much lower level of expression was detected in the lung, stomach, small intestine, and large intestine. Expression of
IL-11
was not detected between day 10.5 and day 18.5 post coitum of embryonic development or in differentiating ES cells in vitro. In contrast, the IL-11R alpha was found to be expressed in all adult tissues examined, during embryonic development, and in totipotent and differentiating ES cells.
...
PMID:Expression of murine interleukin 11 and its receptor alpha-chain in adult and embryonic tissues. 909 Jul 88
