Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.27.1 (
RNase
)
16,360
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
By the method of
RNase
protection, the 5' ends of the
basonuclin
mRNA were mapped to four sites distributed over 400 bases of the genomic sequence, a result implying four different
basonuclin
transcripts within the cell. Despite the heterogeneity at the 5' end, all four
basonuclin
mRNA shared the same translation initiation codon. However, only two transcripts contained, in their 5' untranslated region (UTR), a GC-rich sequence of approx. 180 bases. The ability of this GC-rich sequence to form a large and stable secondary structure was suggested by experimental results from primer extension,
RNase
resistance, and computer analysis of the sequence. In vitro study showed that translation of
basonuclin
RNA containing this putative structure could not be initiated efficiently from the first two AUGs, whereas those that lacked it could.
...
PMID:A GC-rich sequence within the 5' untranslated region of human basonuclin mRNA inhibits its translation. 1052 34
