Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.27.1 (RNase)
 16,360 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bicarbonate (NaHCO3) stress was usually considered to be a mixed stress with salts and high pH. The NaHCO3-specific signaling in plants were rarely reported. In this study, transcriptome analyses was conducted in order to identify the NaHCO3-specific singling in Arabidopsis. Weighted correlation network analysis were performed to isolate the NaHCO3-specific modules in comparison to acetate treatment. The genes in the NaHCO3-root-specific module, which exhibited opposite expressions between NaHCO3 and sodium acetate treatments, were further examined with their corresponding knock-out mutants. The gene Exclusively Bicarbonate Sensitive 1 (EBS1) encoding an S-ribonuclease binding protein was identified to be specifically involved in plant tolerance to NaHCO3, but not to the other two alkaline salts, acetate and phosphate. We also identified the genes that commonly regulated by bicarbonate, acetate and phosphate. Multiple brassinosteroid associated gene ontology terms were enriched in these genes. Via genetic assays, it was found that brassinosteroid signaling positively regulated plant tolerance to NaHCO3 stress while negatively regulated tolerance to acetate and phosphate. Overall, our data genetically identified the bicarbonate-specific genes, and conclude that alkaline stress is mainly dependent on the specificities of the weak acid ions rather than high pH.
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PMID:An S-ribonuclease binding protein EBS1 and brassinolide signaling are specifically required for Arabidopsis tolerance to bicarbonate. 3316 37


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