Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.27.1 (
RNase
)
16,360
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially for elderly patients. Administration of
RNase
has been reported to exhibit neuroprotective effects in acute stroke. However, the potential role of
RNase
on POCD is unknown. Therefore, we sought to investigate whether
RNase
treatment could mitigate unilateral nephrectomy induced-
cognitive deficit
in aged mice. In the present study, twelve-month-old mice were administered
RNase
or an equal amount of normal saline perioperatively. All mice underwent Morris Water Maze (MWM) training 3 times per day for 7 days to acclimatize them to the water maze before surgical operation, and testing on days 1, 3 and 7 after surgery. We found that perioperative administration of
RNase
: 1) attenuated unilateral nephrectomy-induced cognitive impairment at day 3 after surgery; 2) reduced the hippocampal cytokines mRNA production and serum cytokines protein production at day 1 and day 7 (for MCP-1) after surgery, and; 3) inhibited hippocampal apoptosis as indicated by cleaved caspase-3 western blot and TUNEL staining at day 1 after surgery. In addition, a trend decrease of total serum RNA levels was detected in the
RNase
treated group after surgery compared with the untreated group. Further, our protocol of
RNase
administration had no impact on the arterial blood gas analysis right after surgery, kidney function and mortality rate at the observed days postoperatively. In conclusion, perioperative
RNase
treatment attenuated unilateral nephrectomy-induced cognitive impairment in aged mice.
...
PMID:Protective Effect of RNase on Unilateral Nephrectomy-Induced Postoperative Cognitive Dysfunction in Aged Mice. 2622 60
