Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.26.9 (
ribonuclease
)
6,589
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report the identification and characterization of the gene encoding the eighth and final human
ribonuclease
(
RNase
) of the highly diversified RNase A superfamily. The
RNase 8
gene is linked to seven other RNase A superfamily genes on chromosome 14. It is expressed prominently in the placenta, but is not detected in any other tissues examined. Phylogenetic analysis suggests that RNase 7 is the closest relative of
RNase 8
and that the pair likely resulted from a recent gene duplication event in primates. Further analysis reveals that the
RNase 8
gene has incorporated non-silent mutations at an elevated rate (1.3 x 10(-9) substitutions/site/year) and that orthologous
RNase 8
genes from 6 of 10 primate species examined have been deactivated by frameshifting deletions or point mutations at crucial structural or catalytic residues. The ribonucleolytic activity of recombinant human
RNase 8
is among the lowest of members of this superfamily and it exhibits neither antiviral nor antibacterial activities characteristic of some other RNase A ribonucleases. The rapid evolution, species-limited deactivation and tissue-specific expression of
RNase 8
suggest a unique physiological function and reiterates the evolutionary plasticity of the RNase A superfamily.
...
PMID:RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. 1186 8
