Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.26.9 (
ribonuclease
)
6,589
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In the present work, we investigated whether IGF-1 regulates the transcription of the genes encoding the L-type Ca2+ channel (
DHPR
) channel and RyR1 in young adult and senescent mice. To this end, a transgenic mouse model overexpressing IGF-1 exclusively in skeletal muscle (S1S2) was studied at different ages and the results were compared with wild type age-matched mice (FVB). We found that ribosomal RNA expression did not change significantly either with age or IGF-1 according to
ribonuclease
protection and nuclear run-on transcription assays. Transgenic overexpression of IGF-1 resulted in marked increases in skeletal muscle
DHPR
alpha(1S) and RyR1 mRNA in young and old mice and in enhanced
DHPR
alpha(1S) nuclear transcription in skeletal muscles from young mice when normalized to 28S ribosomal RNA. These results support the concept that IGF-1 regulates the expression of
DHPR
by modulating
DHPR
alpha(1S) nuclear transcription.
...
PMID:Age-dependent IGF-1 regulation of gene transcription of Ca2+ channels in skeletal muscle. 1124 Jan 60
