Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.26.9 (ribonuclease)
 6,589 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although serum ribonuclease (RNAase) activity (measured by Reddi's method [1]) was significantly higher in 24 patients with pancreatic carcinoma (mean 12.5 units) than in 93 control subjects (mean 5.0 units), 14 patients with chronic pancreatitis (mean 5.2 units) and 83 patients with other primary malignancies (mean 6.8 units), there was much overlap between the four groups and considerable (16.5%) inter-assay variation. Modification of the assay to eliminate a substrate inhibition effect gave acceptable inter-assay variation but abolished any significant difference between the four groups. Changes in serum RNAase activity did not reflect clinical changes in patients with pancreatic carcinoma followed serially during a trial of chemotherapy. The results indicate that serum RNAase is not a useful marker of pancreatic carcinoma.
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PMID:Serum ribonuclease in the diagnosis of pancreatic carcinoma and in monitoring chemotherapy. 713 41

The so-called "plasma" ribonuclease (RNase), described as increased in most patients with pancreatic cancer, was studied in the blood of 92 subjects utilizing the method of Reddi and Holland, to evaluate its reliability in detecting pancreatic tumors. A significant increase of "plasma" RNase was found in pancreatic cancer (p less than 0.01) as compared with controls, non-calcifying chronic pancreatitis (p less than 0.01), calcifying chronic pancreatitis (p less than 0.01), and chronic recurrent pancreatitis (p less than 0.01). Nevertheless increased "plasma" RNase activity was also found in 18/43 patients with chronic pancreatitis, as well as in the majority of the non-pancreatic malignant tumors studied. Furthermore, in 2 out of 22 subjects with pancreatic cancer the enzyme activity was found to be normal. These data suggest that increased "plasma" RNase, although very frequent in pancreatic cancer, is not a marker of pancreatic malignancy.
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PMID:"Plasma"-type ribonuclease in pancreatic cancer diagnosis: a critical appraisal. 734 12

The serum levels of a poly-[C]-specific acid ribonuclease (RNase) found in the pancreas was measured in 40 normal persons and 137 patients with pancreatic cancer, other cancers, obstructive jaundice, acute pancreatitis or chronic pancreatitis. Serum RNase increased by as much as 800 percent above normal in 69 percent of patients with pancreatic cancer. Analysis of the serum isoenzymes of RNase by isoelectric focusing did not reveal any unique RNases produced by the tumours. In contrast, serum RNase rose in only 8 percent of patients with other cancers, 11 percent of other patients with obstructive jaundice and in no patients with chronic pancreatitis. These data suggest that the finding of increased serum RNase is of adjunctive value inthe diagnosis of pancreatic carcinoma and may be particularly helpful in distinguishing it from other causes of biliary obstruction and from chronic pancreatitis.
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PMID:Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer. 735 Aug 42


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