Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.26.5 (
RNase P
)
1,348
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The activity of
ribonuclease P
on precursor tRNA substrates from Escherichia coli can be abolished by pretreatment of this enzyme with micrococcal nuclease or
pancreatic ribonuclease
A, as well as by proteases and by thermal denaturation. Highly purified
RNase P
exhibits one prominent RNA and one prominent polypeptide component when examined in polyacrylamide gels containing sodium dodecyl sulfate. The buoyant density in CsCl of
RNase P
, 1.71 g/ml, is characteristic of a protein-RNA complex. The activity of
RNase P
is inhibited by various RNA molecules. The presence of a discrete RNA component in
RNase P
appears to be essential for enzymatic function. A model is described for enzyme-substrate recognition in which this RNA component plays an important role.
...
PMID:Ribonuclease P: an enzyme with an essential RNA component. 35 97
