Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.26.5 (
RNase P
)
1,348
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
RNase P
from Escherichia coli cleaves the coenzyme
B12
riboswitch from E. coli and a similar one from Bacillus subtilis. The cleavage sites do not occur in any recognizable structure, as judged from theoretical schemes that have been drawn for these 5' UTRs. However, it is possible to draw a scheme that is a good representation of the E. coli cleavage site for
RNase P
and for the cleavage site in B. subtilis. These data indicate that transient structures are important in
RNase P
cleavage and in riboswitch function. Coenzyme B12 has a small inhibitory effect on E. coli
RNase P
cleavage of the E. coli riboswitch. Both E. coli
RNase P
and a partially purified
RNase P
from Aspergillus nidulans mycelia succeeded in cleaving a putative arginine riboswitch from A. nidulans. The cleavage site may be a representative of another model substrate for eukaryotic
RNase P
. This 5' UTR controls splicing of the arginase mRNA in A. nidulans. Four other riboswitches in E. coli were not cleaved by
RNase P
under the conditions tested.
...
PMID:RNase P cleaves transient structures in some riboswitches. 1606 11
