Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.26.5 (
RNase P
)
1,348
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of five different anthralin concentrations on tRNA biogenesis was investigated employing the
ribonuclease P
(
RNase P
) of the slime mold Dictyostelium discoideum as an in vitro cell-free experimental system.
RNase P
is an ubiquitous and essential enzyme that endonucleolytically cleaves all tRNA precursors to produce the mature 5' end.
Anthralin
revealed a dose-dependent inhibition of
RNase P
activity indicating that this compound may have a direct effect on tRNA biogenesis. Taking into account that anthralin has no structural similarities to the substrate (pre-tRNA) of
RNase P
, it seems reasonable to suggest that this compound may bind to allosteric inhibition sites of the enzyme.
...
PMID:Dose-dependent inhibition of ribonuclease P activity by anthralin. 1075 61
