Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.26.4 (
RNase H
)
2,751
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Less purified fractions of
ribonuclease H
IIa activity of calf thymus display divalent cation-dependent
ribonuclease H
activity and divalent cation-independent ribonuclease activity. Because the ratio of the two enzyme activities does not change during successive chromatographic procedures, we suggest that
ribonuclease H
IIa activity is indeed able to degrade both ssRNA and the RNA moiety of RNA.DNA-hybrids. Ribonuclease H IIa activity can therefore be differentiated from
calf thymus ribonuclease H
I and H IIb by its lack of
ribonuclease H
specificity. The native molecular mass of
ribonuclease H
IIa activity is between 23 and
28 kDa
. Under denaturing conditions a 23 kDa-protein band copurifies with the enzyme activity suggesting that this enzyme is monomeric.
...
PMID:Calf thymus ribonuclease H IIa activity lacks ribonuclease H specificity. 169 Jan 46
