Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.26.4 (
RNase H
)
2,751
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Dimethoxytritylphosphono-oligonucleotide conjugates have been prepared. They are totally resistant to nucleases present in human serum and do not affect cleavage of a complementary oligoribonucleotide by
RNase H
. Conjugates possessing a phosphate backbone gave better antisense inhibition of expression of
plasminogen activator inhibitor
type-1 within endothelial cells as compared with unconjugated oligonucleotides.
...
PMID:Synthesis, biochemical and biological studies on oligonucleotides bearing a lipophilic dimethoxytrityl group. 970 93
