Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.26.4 (
RNase H
)
2,751
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Proteins must acquire and maintain a specific fold to execute their biochemical function(s). In solution, unfolded proteins typically find this native structure through a biased sampling of preferred intermediate conformations. However, the initial search for these structures begins during protein synthesis, and it is unclear how much interactions between the ribosome and nascent polypeptide skew folding pathways. In this issue,
Jensen
and colleagues use a ribosomal force-profiling assay to show that
RNase H
forms a similar folding intermediate on and off the ribosome. In conjunction with measurements of the rate of
RNase H
unfolding on and off the ribosome, their results show that ribosomal interactions have little impact on the folding pathway of
RNase H
. These findings suggest that the ribosome itself does not necessarily rewire protein folding reactions.
...
PMID:A protein folding intermediate pulls its weight. 3281 26
