Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.26.3 (RNase III)
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Human Gene/Protein
Ribonuclease 3 14.9
RNase III 14.2
EIF2C4 13.4
HMGXB3 13.4
RPL18A 12.9
IBtk 12.9
EIF2C3 12.6
MRPL3 12.1
PNPase 11.9
Coactosin-like protein 11.9
EIF2C1 11.9
DiGeorge syndrome critical region gene 8 11.9
RNase E 11.8
Prp4p 11.8
BCD1 11.8
RPL7A 11.8
BCDIN3D 11.8
DGCR8 11.7
Dicer 11.6
DCL1 11.5
ZCCHC6 11.5
cytochrome c oxidase assembly protein 11.4
IBTK 11.2
ZCCHC11 11.1
AIM2 protein 11.1
MKLP2 11.1
hPMC2 11.1
TUTase 11.1
DCR2 11.0
PIWIL3 11.0
SP82 11.0
TRBP 10.9
Endoribonuclease 10.9
ribosomal protein S15 10.8
polynucleotide phosphorylase 10.7
calcium binding and coiled-coil domain 2 10.6
staufen 10.6
DBP1 10.5
DICER1 10.5
GNN 10.2
poly(A)-specific ribonuclease 10.2
GDE1 10.1
DBR1 10.0
Exportin-5 10.0
RTL1 10.0
CAF2 10.0
RET1 10.0
RPS12 9.9
CR6-interacting factor 1 9.9
Peripheral myelin protein 22 9.9
Zn-finger protein 9.8
p19 protein 9.7
Rrp6p 9.6
CPEB3 9.5
ribosomal protein L12 9.5
PRP3 9.5
translation initiation factor IF2 9.4
PACT 9.4
TARBP2 9.4
Rnd2 9.4
RRF 9.4
60kD 9.4
Argonaute-2 9.3
AGO4 9.3
ATP1B1 9.3
BI-1 9.3
ribosomal protein S5 9.2
ARGONAUTE 1 9.2
MT-ND6 9.1
RFN 9.0
ACAA 9.0
GLD-2 9.0
CLEC5A 8.8
PARN 8.8
3' exoribonuclease 8.8
eIF6 8.8
RNA binding motif 8.7
ISG20 8.7
CASP5 8.6
p68 RNA helicase 8.5
more...
Disease
XRN 10.0
EBSS 9.4
Sertoli-Leydig cell tumor 8.4
Sertoli-Leydig cell tumor 8.4
PPB 8.1
acute bacterial endocarditis 7.9
kidney hypertrophy 7.3
Renal fibrosis 6.3
hereditary neuropathy 6.3
Sweet 6.0
Angiosarcoma 6.0
Rocky Mountain spotted fever 5.6
DiGeorge syndrome 5.6
Brucella melitensis 5.5
multinodular goiter 5.3
papillary thyroid cancer 5.3
embryonal rhabdomyosarcoma 5.3
genital infection 5.1
typhus 4.7
APL 4.5
African trypanosomiasis 4.4
PCC 4.4
renal cyst 4.4
autoimmune thyroid disease 4.4
premature ovarian failure 4.3
macrocephaly 4.3
FBS 4.1
PAM 4.1
B-cell lymphomas 4.0
mucormycosis 3.9
Q fever 3.8
chlorosis 3.8
AGS 3.8
Moore 3.8
PIN 3.8
Ewing's sarcoma 3.7
Age-related macular degeneration 3.7
HGF 3.6
Proteus 3.5
idiopathic pulmonary fibrosis 3.5
Shigella flexneri 3.4
PGA 3.3
polymyositis 3.2
NS3 3.2
Legionella 3.2
stromal tumors 3.2
vaccinia 3.1
Lyme disease 3.1
azoospermia 3.1
pheochromocytoma 3.1
Dissociation 3.0
obstructive jaundice 3.0
angiosarcoma 2.9
mouth disease 2.9
epididymis 2.9
WT1 2.9
lymphoproliferative disorders 2.9
DM1 2.9
stomatitis 2.8
medulloblastoma 2.7
interstitial lung disease 2.7
hepatitis C 2.7
Yersinia 2.7
male infertility 2.5
virus infection 2.5
zoonosis 2.5
Pituitary 2.5
oral cancer 2.5
worms 2.5
gastroenteritis 2.5
tumorigenesis 2.4
scleroderma 2.4
mimicry 2.4
dental caries 2.4
Shigella 2.3
infertility 2.3
hepatitis A 2.2
idiopathic thrombocytopenic purpura 2.2
PDB 2.2
pulmonary fibrosis 2.2
more...
Symptom
starvation 2.9
hypotonia 2.4
ataxia 1.0
hypothermia 0.9
fatigue -0.7
diarrhea -0.9
Drug
Cobalamin 6.9
Glutamic acid 5.9
ETS 5.9
Doxycycline 5.8
CED 5.8
AGG 5.3
Vitamin B12 4.7
NBT 4.6
balanced salt solution 4.3
DM1 4.3
G418 3.8
Alliance 3.6
Alanine 3.5
IFN-beta 3.4
DNase I 2.9
Bifidobacterium 2.4
NH3 2.2
EE2 2.0
lactose 1.9
nitroglycerin 1.8
lysine 1.7
citric acid 1.7
Asn 1.4
Nephron 1.4
MAP 1.0
Nephron 0.8
ROS 0.7
NADH 0.5
IFN-gamma 0.1
CSF 0.0
Enzyme
RNase III 14.9
Escherichia coli exonuclease III 12.1
RNase M5 12.1
polynucleotide phosphorylase 11.0
PdxJ 10.9
exoribonuclease 10.3
poly(A)-specific ribonuclease 10.2
exodeoxyribonuclease 10.2
poly(A)-specific ribonuclease 10.1
RNase D 9.9
thiogalactoside transacetylase 9.7
NADH kinase 9.6
dihydroneopterin aldolase 9.3
TUT 9.2
poly(A) polymerase 8.9
RNase PH 8.9
RNA ligase 8.9
RNase P 8.9
purine nucleoside phosphorylase 8.9
Dm-dNK 8.8
RNase T1 8.6
CFA synthase 8.5
FtsH protease 8.4
RNase 8.1
RNase 8.0
tRNase Z 7.9
riboflavin synthase 7.8
ribonuclease 7.8
ribonuclease 7.8
endonuclease 7.4
acyl carrier protein synthase 7.3
HC-Pro 7.3
lambda exonuclease 7.2
exonuclease I 7.1
S1 nuclease 7.0
RNase H 6.7
pullulanase 6.4
isoamylase 6.4
catechol 1,2-dioxygenase 6.4
3'-exonuclease 6.3
succinyl-CoA synthetase 6.3
acetate kinase 6.0
deoxyribonuclease 6.0
deoxyribonuclease 5.9
RNA polymerase 5.7
galactokinase 5.7
cellulose synthase 5.6
SPC 5.6
polynucleotide kinase 5.5
chalcone synthase 5.4
arginine deiminase 5.2
transcriptase 5.0
SCS 5.0
DNase 4.8
cellulose synthase 4.6
DNA ligase 4.5
DNA ligase 4.5
ribonucleotide reductase 4.5
ribonucleotide reductase 4.4
beta-galactosidase 4.3
PTA 4.2
nitrite reductase 4.1
enolase 4.1
PAM 4.1
nitrite reductase 4.1
nitrite reductase 4.0
PRE 4.0
NADH dehydrogenase 3.9
kinesin 3.6
isocitrate dehydrogenase 3.3
caspase-1 3.3
isocitrate dehydrogenase 3.2
thymidylate synthase 3.1
reverse transcriptase 3.0
proteinase K 2.9
MMP 2.9
DNA polymerase 2.9
complex I 2.8
citrate synthase 2.8
luciferase 2.5
more...
Compound
Actinorhodin 10.7
NMOR 9.6
Hygromycin B 8.8
DCL 8.6
Dimethyl fumarate 7.8
Uridine 6.9
Cobalamin 6.9
Ethidium bromide 6.5
TAR 5.9
Doxycycline 5.9
Uracil 5.4
TAP 5.3
HfO2 5.2
PAP 5.1
PAP 4.9
PAP 4.9
HBr 4.8
DAP 4.8
PAP 4.8
DAP 4.8
NBT 4.5
Agarose 4.4
uridine 4.3
tert-butyl hydroperoxide 4.3
Gemcitabine 4.3
Gemcitabine 4.2
Lac 4.2
C2H2 4.1
morpholine 4.1
PAM 4.0
PAM 4.0
DTT 4.0
Piper 4.0
glutamic acid 3.9
DTT 3.9
Mg2+ 3.8
PAM 3.6
Alanine 3.6
Austin 3.5
CIT 3.5
manganese 3.4
isoquinoline 3.4
CTP 3.4
formamide 3.3
Serine 3.2
Adenosine 3.2
BRL 3.1
PDB 3.1
CAP 3.1
Ile 2.9
ABA 2.8
Resveratrol 2.8
Chitosan 2.8
guanidine 2.8
PGA 2.7
UTP 2.7
betaine 2.7
Guo 2.7
MgCl2 2.7
THP 2.6
aspartic acid 2.6
aspartic acid 2.6
THP 2.6
ABA 2.6
salt 2.5
Neuronal 2.5
GSSG 2.5
aspartic acid 2.4
alanine 2.4
Retinal 2.4
ubiquinone 2.4
DNA 2.3
Estradiol 2.3
A 1 2.3
aspartic acid 2.3
Diazepam 2.3
glutamine 2.2
phosphate 2.2
GTP 2.1
methionine 2.1
more...