Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.26.3 (RNase III)
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Human Gene/Protein
Ribonuclease 3 14.9
RNase III 14.2
EIF2C4 13.4
HMGXB3 13.4
IBtk 12.9
RPL18A 12.9
EIF2C3 12.6
MRPL3 12.1
PNPase 11.9
DiGeorge syndrome critical region gene 8 11.9
Coactosin-like protein 11.9
EIF2C1 11.9
RNase E 11.8
BCD1 11.8
BCDIN3D 11.8
RPL7A 11.8
Prp4p 11.8
DGCR8 11.7
Dicer 11.6
DCL1 11.5
ZCCHC6 11.5
cytochrome c oxidase assembly protein 11.4
IBTK 11.2
hPMC2 11.1
AIM2 protein 11.1
MKLP2 11.1
ZCCHC11 11.1
TUTase 11.1
DCR2 11.0
PIWIL3 11.0
SP82 11.0
TRBP 10.9
Endoribonuclease 10.9
ribosomal protein S15 10.8
polynucleotide phosphorylase 10.7
calcium binding and coiled-coil domain 2 10.6
staufen 10.6
DBP1 10.5
DICER1 10.5
GNN 10.2
poly(A)-specific ribonuclease 10.2
GDE1 10.1
DBR1 10.0
Exportin-5 10.0
RTL1 10.0
RET1 10.0
CAF2 10.0
CR6-interacting factor 1 9.9
RPS12 9.9
Peripheral myelin protein 22 9.9
Zn-finger protein 9.8
p19 protein 9.7
Rrp6p 9.6
CPEB3 9.5
PRP3 9.5
ribosomal protein L12 9.5
PACT 9.4
translation initiation factor IF2 9.4
TARBP2 9.4
Rnd2 9.4
RRF 9.4
60kD 9.4
Argonaute-2 9.3
AGO4 9.3
BI-1 9.3
ATP1B1 9.3
ribosomal protein S5 9.2
ARGONAUTE 1 9.2
MT-ND6 9.1
RFN 9.0
ACAA 9.0
GLD-2 9.0
CLEC5A 8.8
eIF6 8.8
3' exoribonuclease 8.8
PARN 8.8
RNA binding motif 8.7
ISG20 8.7
CASP5 8.6
p68 RNA helicase 8.5
PIWIL4 8.5
DSS1 8.5
CLC-5 8.5
ribosomal protein L3 8.4
RISC 8.4
MAP-1 8.4
dbpA 8.4
OUT 8.3
muscle LIM protein 8.3
RNase 8.2
SRAP 8.2
secreted frizzled-related protein 1 8.2
IGF2BP2 8.2
U4/U6.U5 8.2
SRp20 8.2
cysteine endopeptidase 8.2
FZD4 8.1
pre-mRNA splicing factor 8.1
DCR 8.1
E3 protein 8.1
METTL14 8.0
tRNase Z 8.0
nucleostemin 8.0
PIWI 8.0
ribonuclease P 7.9
Era 7.9
MNB 7.9
MCAK 7.9
MIWI 7.9
SP7 7.8
PDCD4 7.8
PE1 7.8
NF90 7.7
NDP52 7.7
ALG-2 7.7
U1A 7.6
actin beta 7.6
CHO1 7.6
ATP-dependent RNA helicase 7.5
L12 7.5
RNA helicase 7.5
Fibroblast growth factor receptor 2 7.5
Proopiomelanocortin 7.4
CAF1 7.4
DRB4 7.4
RNase A 7.4
SIII 7.4
DNA-dependent DNA polymerase 7.4
RAC 7.4
endonuclease 7.4
Stanniocalcin-1 7.3
RNA-associated 7.3
p68 7.3
Piwil2 7.2
L10 7.1
Delta3 7.1
Ig-alpha 7.1
MAPK14 7.0
ARD 7.0
Angiogenin 7.0
non-protein coding 7.0
CBP80 7.0
leucine-rich repeat protein 7.0
RNA binding protein 7.0
ADAR2 7.0
IF2 7.0
EF-Ts 7.0
MAP1LC3B 6.9
exonuclease I 6.9
RNase H1 6.9
E.coli 6.9
E2F2 6.9
Helicase 6.9
zinc finger motif 6.9
CENP-E 6.9
processed form 6.9
sorcin 6.8
RNA-binding protein 6.8
Q10 6.8
signal peptidase 6.8
AGO1 6.8
signal recognition particle 6.8
p72 6.7
L11 6.7
XPO1 6.6
NAP1 6.6
DEAD-box RNA helicase 6.6
AURKA 6.5
DAI 6.5
PKR 6.5
RIS 6.5
collagen VII 6.5
Vps34 6.5
RNase H 6.5
p23 6.5
SMARCA4 6.5
ADAR 6.4
PIR 6.4
L18 6.4
Kip2 6.4
NeuroD1 6.3
p19 6.3
MRP 6.3
Pyruvate dehydrogenase 6.2
variant 1 6.2
tristetraprolin 6.2
GSC 6.2
AQP2 6.1
ICAM-1 mRNA 6.1
dynamin 2 6.1
SUMO1 6.1
ADAR1 6.1
sequestosome 1 6.1
ND3 6.1
ribosomal protein 6.1
GCN5 6.1
AGO 6.1
Zinc finger 6.1
TER 6.1
tyrosyl-tRNA synthetase 6.0
MS2 6.0
helicase 6.0
ORF4 6.0
Eg5 6.0
p20 6.0
ribonucleoprotein 6.0
3'-5' exonuclease 6.0
EF-Tu 6.0
AQP3 5.9
TOP 5.9
C. elegans) 5.9
LSC 5.9
PRC1 5.9
P27 5.8
BRG1 5.8
CAF 5.8
OXPHOS 5.8
ACTB 5.8
COII 5.7
ABL1 5.7
galactokinase 5.7
zinc finger protein 5.6
translation initiation factor 5.6
CD49f 5.6
AIM2 5.6
p22 5.6
GATA1 5.6
intestinal alkaline phosphatase 5.5
kid 5.5
YAP1 5.5
Patched 5.5
Maf 5.5
elongation factor G 5.5
UTR 5.5
TAL1 5.5
snRNP 5.5
NKp46 5.5
deoxyribonuclease 5.5
BACE 5.5
MDA5 5.5
melastatin 5.4
ghrelin receptor 5.4
CLIP 5.4
ISG15 5.4
RNA polymerase II 5.4
TLR8 5.4
P40 5.4
NAP 5.4
Werner syndrome 5.4
MEF 5.3
DEAD 5.3
CED 5.3
p57 5.3
nucleolar protein 5.3
DNA ligase 5.3
putative transcription factor 5.3
TAP 5.3
AQP4 5.2
GSR 5.2
merlin 5.2
microphthalmia-associated transcription factor 5.2
osterix 5.2
eosinophil cationic protein 5.2
Nestin 5.1
PAP 5.1
Ribonuclease 5.1
metallopeptidase 5.1
initiation factor 2 5.1
CRM1 5.0
fructose-1,6-bisphosphatase 5.0
nucleotide pyrophosphatase 5.0
HuR 5.0
tRNA 5.0
nucleoside diphosphate kinase 5.0
GTP-binding protein 4.9
ZIP 4.9
CD1d 4.9
aP2 4.9
Bruton's tyrosine kinase 4.9
inhibitor-1 4.8
DAP 4.8
P16 4.8
DNase 4.8
RIG-I 4.8
p25 4.7
type I interferon 4.7
unknown function 4.6
Proteinase 4.6
EP2 4.6
FAM 4.6
alternatively spliced 4.6
PCC 4.6
Reelin 4.5
Caspase-1 4.5
LC3B 4.5
ribonucleotide reductase 4.5
BAFF 4.4
A-II 4.4
MRP1 4.4
glutaredoxin 4.4
GAA 4.4
C2H2 4.4
GSK3 4.4
ORF 4.3
activation-induced cytidine deaminase 4.3
EP4 4.3
SRC 4.3
D. melanogaster 4.3
non-catalytic 4.3
protein disulfide isomerase 4.2
CCA 4.2
extracellular protein 4.2
cysteine proteinase 4.2
ribosomal protein S6 4.2
interferon-beta 4.2
ORF1 4.2
DM1 4.2
PAM 4.2
tumor suppressor protein 4.2
FBS 4.2
more...
Disease
XRN 10.0
EBSS 9.4
Sertoli-Leydig cell tumor 8.4
Sertoli-Leydig cell tumor 8.4
PPB 8.1
acute bacterial endocarditis 7.9
kidney hypertrophy 7.3
Renal fibrosis 6.3
hereditary neuropathy 6.3
Sweet 6.0
Angiosarcoma 6.0
Rocky Mountain spotted fever 5.6
DiGeorge syndrome 5.6
Brucella melitensis 5.5
multinodular goiter 5.3
papillary thyroid cancer 5.3
embryonal rhabdomyosarcoma 5.3
genital infection 5.1
typhus 4.7
APL 4.5
African trypanosomiasis 4.4
PCC 4.4
renal cyst 4.4
autoimmune thyroid disease 4.4
premature ovarian failure 4.3
macrocephaly 4.3
FBS 4.1
PAM 4.1
B-cell lymphomas 4.0
mucormycosis 3.9
Q fever 3.8
chlorosis 3.8
AGS 3.8
Moore 3.8
PIN 3.8
Ewing's sarcoma 3.7
Age-related macular degeneration 3.7
HGF 3.6
Proteus 3.5
idiopathic pulmonary fibrosis 3.5
Shigella flexneri 3.4
PGA 3.3
polymyositis 3.2
NS3 3.2
Legionella 3.2
stromal tumors 3.2
vaccinia 3.1
Lyme disease 3.1
azoospermia 3.1
pheochromocytoma 3.1
Dissociation 3.0
obstructive jaundice 3.0
angiosarcoma 2.9
mouth disease 2.9
epididymis 2.9
WT1 2.9
lymphoproliferative disorders 2.9
DM1 2.9
stomatitis 2.8
medulloblastoma 2.7
interstitial lung disease 2.7
hepatitis C 2.7
Yersinia 2.7
male infertility 2.5
virus infection 2.5
zoonosis 2.5
Pituitary 2.5
oral cancer 2.5
worms 2.5
gastroenteritis 2.5
tumorigenesis 2.4
scleroderma 2.4
mimicry 2.4
dental caries 2.4
Shigella 2.3
infertility 2.3
hepatitis A 2.2
idiopathic thrombocytopenic purpura 2.2
PDB 2.2
pulmonary fibrosis 2.2
cold 2.1
macular degeneration 2.1
iron deficiency 2.1
Schistosoma mansoni 2.1
Haemophilus 2.0
anaphylaxis 2.0
developmental delay 1.9
Cryptococcus neoformans 1.9
B-cell lymphoma 1.9
Mycobacterium 1.8
Graves' disease 1.8
Blocking 1.8
glioblastoma 1.8
dilated cardiomyopathy 1.8
neuroblastoma 1.8
MCF 1.7
SARS 1.7
primary tumor 1.6
infestation 1.6
pancreatic cancer 1.6
Syndrome 1.6
dysplasia 1.5
Klebsiella 1.5
glucose intolerance 1.4
Brown 1.3
measles 1.3
Chlamydia 1.3
sarcoma 1.3
HIV 1.3
Huntington's disease 1.2
immunodeficiency 1.1
Mycoplasma 1.1
tuberculosis 1.0
glioma 1.0
fits 1.0
pancreatitis 1.0
blindness 0.9
uterus 0.9
melanoma 0.9
colorectal cancer 0.8
gastric cancer 0.8
Infection 0.7
infectious diseases 0.6
cardiomyopathy 0.6
breast cancer 0.5
leukemia 0.4
Epstein 0.4
SDS 0.3
pneumonia 0.2
tumor 0.2
addiction 0.2
ovarian cancer 0.2
colon cancer 0.1
tumor growth 0.1
cancer 0.0
renal failure -0.0
autism -0.1
acute myeloid leukemia -0.2
lymphoma -0.2
cognitive impairment -0.2
GSH -0.3
osteoporosis -0.3
tumor progression -0.4
multiple sclerosis -0.5
squamous cell carcinoma -0.5
renal disease -0.5
carcinoma -0.7
plaque -0.8
influenza -0.9
prostate cancer -0.9
obesity -1.0
carcinogenesis -1.0
cardiovascular disease -1.1
adenocarcinoma -1.1
heart failure -1.2
West -1.2
atherosclerosis -1.3
Alzheimer's disease -1.8
AIDS -1.9
diabetes -3.1
Symptom
starvation 2.9
hypotonia 2.4
ataxia 1.0
hypothermia 0.9
fatigue -0.7
diarrhea -0.9
Drug
Cobalamin 6.9
Glutamic acid 5.9
ETS 5.9
Doxycycline 5.8
CED 5.8
AGG 5.3
Vitamin B12 4.7
NBT 4.6
balanced salt solution 4.3
DM1 4.3
G418 3.8
Alliance 3.6
Alanine 3.5
IFN-beta 3.4
DNase I 2.9
Bifidobacterium 2.4
NH3 2.2
EE2 2.0
lactose 1.9
nitroglycerin 1.8
lysine 1.7
citric acid 1.7
Asn 1.4
Nephron 1.4
MAP 1.0
Nephron 0.8
ROS 0.7
NADH 0.5
IFN-gamma 0.1
CSF 0.0
Enzyme
RNase III 14.9
Escherichia coli exonuclease III 12.1
RNase M5 12.1
polynucleotide phosphorylase 11.0
PdxJ 10.9
exoribonuclease 10.3
poly(A)-specific ribonuclease 10.2
exodeoxyribonuclease 10.2
poly(A)-specific ribonuclease 10.1
RNase D 9.9
thiogalactoside transacetylase 9.7
NADH kinase 9.6
dihydroneopterin aldolase 9.3
TUT 9.2
poly(A) polymerase 8.9
RNase PH 8.9
RNA ligase 8.9
RNase P 8.9
purine nucleoside phosphorylase 8.9
Dm-dNK 8.8
RNase T1 8.6
CFA synthase 8.5
FtsH protease 8.4
RNase 8.1
RNase 8.0
tRNase Z 7.9
riboflavin synthase 7.8
ribonuclease 7.8
ribonuclease 7.8
endonuclease 7.4
acyl carrier protein synthase 7.3
HC-Pro 7.3
lambda exonuclease 7.2
exonuclease I 7.1
S1 nuclease 7.0
RNase H 6.7
pullulanase 6.4
isoamylase 6.4
catechol 1,2-dioxygenase 6.4
3'-exonuclease 6.3
succinyl-CoA synthetase 6.3
acetate kinase 6.0
deoxyribonuclease 6.0
deoxyribonuclease 5.9
RNA polymerase 5.7
galactokinase 5.7
cellulose synthase 5.6
SPC 5.6
polynucleotide kinase 5.5
chalcone synthase 5.4
arginine deiminase 5.2
transcriptase 5.0
SCS 5.0
DNase 4.8
cellulose synthase 4.6
DNA ligase 4.5
DNA ligase 4.5
ribonucleotide reductase 4.5
ribonucleotide reductase 4.4
beta-galactosidase 4.3
PTA 4.2
nitrite reductase 4.1
enolase 4.1
PAM 4.1
nitrite reductase 4.1
nitrite reductase 4.0
PRE 4.0
NADH dehydrogenase 3.9
kinesin 3.6
isocitrate dehydrogenase 3.3
caspase-1 3.3
isocitrate dehydrogenase 3.2
thymidylate synthase 3.1
reverse transcriptase 3.0
proteinase K 2.9
MMP 2.9
DNA polymerase 2.9
complex I 2.8
citrate synthase 2.8
luciferase 2.5
phosphatidylinositol 3-kinase 2.5
protein kinase 2.4
dihydrofolate reductase 2.4
diaphorase 2.4
phosphodiesterase 2.3
ornithine decarboxylase 2.3
papain 2.3
lysozyme 2.1
NOS 2.1
MAP 2.1
glutathione S-transferase 2.1
cdc2 1.9
lipoxygenase 1.9
cytochrome oxidase 1.8
alcohol dehydrogenase 1.8
glutathione reductase 1.7
CD10 1.7
focal adhesion kinase 1.5
beta-lactamase 1.2
phospholipase A2 1.1
proteasome 1.1
ATPase 0.9
calcineurin 0.9
caspase-3 0.8
MEK 0.8
mitogen-activated protein kinase 0.4
alkaline phosphatase 0.4
catalase 0.2
superoxide dismutase 0.1
renin -0.2
ERK -0.6
protein kinase C -0.7
peroxidase -1.1
ACS -1.3
Compound
Actinorhodin 10.7
NMOR 9.6
Hygromycin B 8.8
DCL 8.6
Dimethyl fumarate 7.8
Uridine 6.9
Cobalamin 6.9
Ethidium bromide 6.5
TAR 5.9
Doxycycline 5.9
Uracil 5.4
TAP 5.3
HfO2 5.2
PAP 5.1
PAP 4.9
PAP 4.9
HBr 4.8
DAP 4.8
PAP 4.8
DAP 4.8
NBT 4.5
Agarose 4.4
uridine 4.3
tert-butyl hydroperoxide 4.3
Gemcitabine 4.3
Gemcitabine 4.2
Lac 4.2
C2H2 4.1
morpholine 4.1
PAM 4.0
PAM 4.0
DTT 4.0
Piper 4.0
glutamic acid 3.9
DTT 3.9
Mg2+ 3.8
PAM 3.6
Alanine 3.6
Austin 3.5
CIT 3.5
manganese 3.4
isoquinoline 3.4
CTP 3.4
formamide 3.3
Serine 3.2
Adenosine 3.2
BRL 3.1
PDB 3.1
CAP 3.1
Ile 2.9
ABA 2.8
Resveratrol 2.8
Chitosan 2.8
guanidine 2.8
PGA 2.7
UTP 2.7
betaine 2.7
Guo 2.7
MgCl2 2.7
THP 2.6
aspartic acid 2.6
aspartic acid 2.6
THP 2.6
ABA 2.6
salt 2.5
Neuronal 2.5
GSSG 2.5
aspartic acid 2.4
alanine 2.4
Retinal 2.4
ubiquinone 2.4
DNA 2.3
Estradiol 2.3
A 1 2.3
aspartic acid 2.3
Diazepam 2.3
glutamine 2.2
phosphate 2.2
GTP 2.1
methionine 2.1
2-oxoglutarate 2.1
DEAE 2.1
A 3 2.0
dUTP 2.0
TNM 2.0
Optimal 1.9
PGE 1.8
TCA 1.8
CAT 1.8
CAT 1.8
BCG 1.8
serine 1.7
MAP 1.7
CAT 1.7
Panam 1.7
Carbon 1.6
palmitic acid 1.6
lysine 1.6
CAM 1.6
urea 1.5
bromide 1.5
N-acetylcysteine 1.5
NADH 1.5
salicylic acid 1.5
GDP 1.5
naphthalene 1.4
hydroxide 1.3
COS 1.3
zinc 1.3
NAD 1.3
ATP 1.2
arginine 1.2
cobalt 1.2
barium 1.0
nicotinamide 0.9
benzene 0.9
acrylamide 0.9
Phe 0.9
Asp 0.8
PEG 0.7
PEG 0.7
His 0.7
pyrene 0.7
pyrimidine 0.6
NAD 0.6
glycerol 0.6
pyrimidine 0.6
threonine 0.5
ammonia 0.5
NH2 0.4
MDA 0.4
glutamate 0.4
NADPH 0.3
NADPH 0.3
phenol 0.2
EDTA 0.2
EDTA 0.2
SDS 0.2
Dec 0.2
iron 0.2
sulfate 0.2
ethanol 0.1
cAMP 0.1
leucine 0.0
ammonium -0.0
proline -0.0
glucose -0.1
Gly -0.1
tryptophan -0.2
tryptophan -0.2
tryptophan -0.2
galactose -0.3
cysteine -0.3
ADP -0.3
ADP -0.3
sodium -0.3
tryptophan -0.4
GSH -0.4
GSH -0.4
ADP -0.4
CO2 -0.5
oxygen -0.6
hydrogen -0.7
nitrate -0.7
nitrogen -0.8
acetate -0.9
silver -0.9
calcium -1.1
ACS -1.3
ACS -1.3
potassium -1.6
nitric oxide -1.6
water -2.1