Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.25.1 (deoxyribonuclease)
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Human Gene/Protein
deoxyribonuclease 13.6
Ubiquitin B 12.8
TNFRSF1A-associated via death domain 12.1
HTF9 11.6
RPC3 11.4
ANKRD30A 11.2
TMPRSS9 11.2
DNASE1L3 11.2
B-ind1 11.1
DNase gamma 11.1
DNASE1 11.0
ADCY7 10.9
DLAD 10.8
Caspase-activated DNase 10.7
deoxyribonuclease II 10.6
CDCA3 10.6
death effector domain-containing 10.6
Fc gamma receptor IIB 10.5
ITM2A 10.5
DFF35 10.5
SPF30 10.4
DNase X 10.4
PARP4 10.2
acid DNase 10.2
THIK-2 10.2
SPC24 10.1
TRIP-1 10.1
SSBP3 9.9
NUCKS1 9.9
DNase II 9.9
Micrococcus luteus UV endonuclease 9.8
KCTD11 9.8
p32 protein 9.6
Ten-m3 9.6
transcription regulator protein 9.6
MT-IG 9.4
AP lyase 9.4
ITGAL 9.3
PIP5K1C 9.2
photolyase 9.2
UBE2I 9.2
DNA repair enzyme 9.1
NBG 9.1
TNF receptor-associated protein 1 9.0
ATP synthase subunit beta 8.9
histone H1t 8.9
phosphomonoesterase 8.9
adenylyl cyclase-associated protein 8.9
endonuclease III 8.8
stanniocalcin 2 8.8
H2A histone family member 8.7
Exonuclease I 8.7
S1-5 8.6
CRISP1 8.6
KNS 8.6
caspase-activated DNase 8.4
carbonic anhydrase B 8.4
WD repeat protein 8.4
DNase 8.4
parotid secretory protein 8.4
ADN 8.4
deoxyribonuclease I 8.4
pancreatic cholesterol esterase 8.4
TNFRSF10B 8.3
beta-polymerase 8.3
exonuclease 1 8.2
DNA replication licensing factor 8.2
FCGR2B 8.2
CRV 8.2
uracil-DNA glycosylase 8.2
Ribonuclease 8.1
ISG20 8.1
SP-10 8.1
high molecular weight mucin 8.1
NAK 8.0
mucin 5AC 8.0
xeroderma pigmentosum variant 8.0
exonuclease I 8.0
GSN 8.0
Exonuclease III 7.9
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Disease
Pleural infection 12.5
Mammary adenocarcinoma 10.1
XP-A 9.3
KNS 9.2
latent virus infection 9.0
Streptococcus pyogenes infection 8.5
Myometrium 8.4
throat infection 8.3
xeroderma pigmentosum 7.9
streptococcal infection 7.4
Staphylococcus aureus endocarditis 7.3
acute bronchiolitis 7.1
Trichinella infection 7.1
Cockayne syndrome 7.0
trichothiodystrophy 6.9
DBA2 6.9
oophoritis 6.8
streptococcal pharyngitis 6.7
plantar warts 6.6
Brucella canis 6.6
glomerulitis 6.6
tonsillar hypertrophy 6.6
erysipelas 6.5
XPG 6.5
Autosomal recessive polycystic kidney disease 6.4
impetigo 6.3
rheumatic fever 6.2
poikiloderma 6.2
recurrent tonsillitis 6.1
acute glomerulonephritis 6.1
empyema 6.0
Shwartzman reaction 6.0
sclerodactyly 5.9
carditis 5.8
acute tonsillitis 5.8
coryza 5.8
Brucella suis 5.7
RP1 5.7
CDT 5.7
Vesicular stomatitis 5.7
pyoderma 5.7
trichinellosis 5.7
pharyngitis 5.5
community acquired pneumonia 5.5
sicca syndrome 5.5
myeloblastosis 5.5
CSB 5.4
CSB 5.3
SSD 5.2
tracheomalacia 5.2
juvenile periodontitis 5.1
reticuloendotheliosis 5.1
skin infection 5.0
cystic fibrosis 5.0
Franklin 4.9
lymphogranuloma venereum 4.9
CREST 4.9
NPS 4.9
RP4 4.9
skin cancer 4.9
pulmonary insufficiency 4.8
NLS 4.7
Lymph nodes 4.7
Lesch-Nyhan syndrome 4.7
lung abscess 4.7
avian sarcoma 4.7
parakeratosis 4.7
rind 4.6
CEP 4.6
ABS 4.6
nonmelanoma skin cancer 4.6
chancroid 4.5
ABS 4.5
tinea 4.4
DMS 4.4
autoimmune thyroiditis 4.4
carcinosarcoma 4.4
avian leukosis 4.4
Venezuelan equine encephalitis 4.3
dermatophytosis 4.3
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Symptom
nocturnal cough 7.6
POA 5.3
adenitis 5.3
persistent cough 5.1
skin damage 4.8
clubbing 4.6
chorea 4.4
Hudson 4.3
muscle rigidity 4.3
sore throat 4.0
acute abdominal pain 3.4
chronic cough 3.4
cough 3.2
masculinization 3.1
erythema 3.0
Ill 2.5
dyspnea 2.2
starvation 2.1
hemoptysis 1.8
arthralgia 1.6
respiratory distress 1.1
agitation 0.8
exhaustion 0.7
anorexia 0.7
collapse 0.6
acidity 0.5
tremor 0.2
diarrhea 0.2
discomfort -0.1
discomfort -0.2
vomiting -0.6
pain -1.6
Drug
Pulmozyme 11.4
Pronase 8.7
Nafcillin 8.4
Neocarzinostatin 7.6
DNase I 6.9
CrCl3 6.9
Mitomycin-C 6.7
Alteplase 6.6
Kaolin 6.5
Rasburicase 6.4
Alteplase 6.4
Alteplase 6.3
CED 6.2
ZnCl2 5.6
ZnCl2 5.6
Hyaluronidase 5.6
anti-RSV 5.5
Hyaluronidase 5.4
Glutamic acid 5.4
TES 5.3
Lactose 5.2
Metrizamide 5.2
Camp 4.9
Ofloxacin 4.7
Fraction 4.7
-deoxyadenosine 4.4
CaCl2 4.4
CaCl2 4.4
CaCl2 4.3
Hypaque 4.3
Hypaque 4.1
Arsenic trioxide 4.1
ABC 3.9
IPM 3.9
Amiloride 3.8
lactose 3.8
GEO 3.8
Coral 3.8
Gel 3.7
Activin 3.7
Gelatin 3.6
Amiloride 3.6
Itraconazole 3.5
Mutagen 3.4
DHT 3.3
DHT 3.2
Glycerol 3.2
ampicillin 3.0
MOF 2.9
MRC 2.7
Asn 2.5
NADH 2.3
Adriamycin 2.2
Albumin 2.2
lysine 1.9
PTH 1.7
NH3 1.6
caffeine 1.6
ROS 1.2
Dermatol 1.1
CTX 1.1
Leaf 1.0
MAP 0.5
Nephron 0.3
ascorbate -0.1
IL-2 -0.4
CSF -0.5
Enzyme
deoxyribonuclease 14.4
deoxyribonuclease 14.0
endodeoxyribonuclease 13.3
yeast ribonuclease 12.8
exodeoxyribonuclease 12.0
endonuclease V 11.9
DNase 11.7
L-fucose dehydrogenase 10.8
DNase II 10.4
AP lyase 9.9
ribonuclease 9.7
ribonuclease 9.7
exonuclease V 9.6
lambda exonuclease 9.5
dCTPase 9.4
rubredoxin reductase 9.4
Escherichia coli exonuclease III 9.1
2',3'-cyclic nucleotide phosphohydrolase 9.0
rhizopuspepsin 8.9
Fpg protein 8.8
PGE2-9-ketoreductase 8.7
phospho-beta-glucosidase 8.7
exonuclease I 8.6
diacetyl reductase 8.5
RNase 8.4
3'-exonuclease 8.3
RNase 8.3
DNA ligase 8.1
DNA ligase 8.1
3'-phosphatase 8.0
glycerophosphodiester phosphodiesterase 8.0
PRE 8.0
micrococcal nuclease 7.3
lysine decarboxylase 7.3
venom phosphodiesterase 7.1
hyaluronate lyase 7.1
hyaluronidase 7.1
protein disulfide-isomerase 7.1
lysostaphin 7.1
nucleoside diphosphokinase 7.1
dCMP deaminase 7.0
carboxypeptidase G2 6.9
hyaluronidase 6.8
amylomaltase 6.7
p-nitrophenylphosphatase 6.7
endonuclease VII 6.7
endonuclease 6.7
uridine kinase 6.7
arginine deiminase 6.6
alpha-sarcin 6.6
acylphosphatase 6.6
histidase 6.5
DNA polymerase 6.4
ADP-ribosyltransferase 6.4
conjugase 6.3
thymidylate kinase 6.2
chondroitinase 6.2
RNase III 6.0
ADP-ribosyltransferase 6.0
lysin 6.0
ficin 6.0
restriction-modification system 6.0
peptidylarginine deiminase 5.9
proteinase K 5.9
triphosphatase 5.8
cathepsin C 5.8
beta-xylosidase 5.8
trypsin 5.7
chymopapain 5.7
hypoxanthine-guanine phosphoribosyltransferase 5.7
heparinase 5.7
NAD glycohydrolase 5.7
chymopapain 5.7
lipase 5.6
lysyl endopeptidase 5.5
tissue plasminogen activator 5.4
nucleotidase 5.4
acid phosphatase 5.3
chondroitinase 5.3
fumarase 5.3
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Compound
Dehydroheliotridine 13.4
4,6-Diamino-5-formamidopyrimidine 12.4
2-Fluoroadenine 11.8
Nitromin 11.4
Gallocyanin 11.1
Pyridoxamine 5'-phosphate 10.9
Deoxyinosine 9.7
deoxyribose-5-phosphate 9.3
Carboquone 9.0
Carboquone 9.0
Carboquone 9.0
Carboquone 9.0
Chondroitin sulfate A 8.6
Picric acid 8.6
Nafcillin 8.5
dITP 8.4
Atractyloside 8.2
Chromomycin A3 8.2
Distamycin A 8.2
Deoxyribonucleic acid 8.1
Deoxyribose 8.1
Cesium chloride 8.1
R 1881 7.9
PTO 7.9
5-Methylcytosine 7.8
IBT 7.7
Oil Red 7.7
Neocarzinostatin 7.6
pyrimidine 7.5
ASK 7.5
pyrimidine 7.5
Coomassie Blue 7.4
DTB 7.3
DTB 7.3
M 3 7.3
Pristane 7.2
DTB 7.2
2-naphthoic acid 6.9
3'-AMP 6.9
Daunomycin 6.9
SC-1 6.8
SC-1 6.8
10-formyltetrahydrofolate 6.7
Lincomycin 6.7
Lincomycin 6.7
Trimethylamine 6.6
MoSe2 6.4
5H-pyrido[4,3-b]indole 6.3
LY 294002 6.2
Nitrofurantoin 6.2
Toluidine blue 6.2
Nalidixic acid 6.1
glucosamine-6-phosphate 6.1
perchloric acid 6.0
Chondroitin 6.0
Puromycin 6.0
Thymine 5.9
DMS 5.8
HN2 5.7
TES 5.7
Naringenin 5.7
dATP 5.7
DEAE 5.7
CTP 5.6
CDT 5.6
5-Azacytidine 5.6
Naringenin 5.6
Mannitol 5.6
Mannitol 5.6
Thymidine 5.6
TTP 5.5
Mg2+ 5.5
Adenine 5.5
methyl methanesulfonate 5.5
Ketoprofen 5.4
Daunorubicin 5.4
dCTP 5.4
XPA 5.4
XPA 5.4
Norfloxacin 5.4
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