Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.25.1 (
deoxyribonuclease
)
1,471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Syntheses of nucleic acids are of importance not only in the natural product chemistry but also in the molecular recognition study in biology. This review describes syntheses of RNA and DNA, which were found to be related each other. Deoxyinosine probes were developed for cloning genes with degenerated codons. Synthetic genes for
c-Ha-ras
and
T4 endonuclease V
provided new approaches in recognition of nucleic acids by proteins. Antibodies specific for photo-damaged pyrimidines in DNA have been studied by cloning and mutating their genes.
...
PMID:[Nucleic acid syntheses and molecular recognition]. 1051 16
The chemical syntheses of genes encoding human
c-Ha-ras
and
T4 endonuclease V
are described. These genes have been used for studies of mutagenesis by damaged bases and recognition of nucleic acids by proteins. The modes of interaction of photo-damaged DNA and cognate antibodies have also been investigated by biochemical and physicochemical approaches.
...
PMID:Nucleic acid synthesis for investigations of gene functions. 1078 Mar 57
