Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.25.1 (
deoxyribonuclease
)
1,471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The data are provided on the immune status in 108 patients with
chronic pancreatitis
. The authors revealed the immune responses toward pancreatic tissue, deoxyribonucleic acid and
deoxyribonuclease
. Based on the revealed autoimmune responses to the pancreatic tissue, two patterns of
chronic pancreatitis
were distinguished: the immunopositive and immunonegative. It is suggested that immunologic mechanisms are involved into the pathogenesis of the immunopositive pattern of
chronic pancreatitis
.
...
PMID:[Immunopositive and immunonegative forms of chronic pancreatitis]. 387 18
Serum ribonuclease (RNase) and
deoxyribonuclease
(
DNase
) were investigated in 18 control subjects, and in 22 patients with pancreatic cancer, 13 with
chronic pancreatitis
and 29 with extrapancreatic diseases in order to assess their clinical usefulness in pancreatic cancer diagnosis and to evaluate whether modifications were consensual and/or age-related. Increased
DNase
and RNase values were found not only in a notable proportion of pancreatic cancer, but also in
chronic pancreatitis
and extra-pancreatic diseases. Thus the clinical value of both enzymes in pancreatic cancer diagnosis is negligible.
DNase
does not seem to be strictly age-dependent, whereas serum RNase does. Elevated levels of the two enzymes, when present, were consensual, suggesting that factors involved in such an increase were partially common to both.
...
PMID:Serum deoxyribonuclease and ribonuclease in pancreatic cancer and chronic pancreatitis. 408 85
