Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.22.1 (DNase II)
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Human Gene/Protein
deoxyribonuclease II 16.2
DNase II 16.2
acid DNase 16.1
Deoxyribonuclease II 15.9
DNASE2 15.3
DLAD 14.7
3',5'-cyclic AMP phosphodiesterase 13.6
crn 13.0
DNASE1L2 12.9
DNase X 12.8
G-protein coupled receptor protein 12.4
anti-elastase 12.1
caspase-activated DNase 12.1
NUC 11.6
80kD 11.6
Caspase-activated DNase 11.5
cyclophilin C 11.0
CAD protein 11.0
CRV 11.0
DNase gamma 10.9
NHP2 10.9
Poly(ADP-ribose) glycohydrolase 10.8
S1-5 10.4
GST T1 10.4
DNase 10.2
endonuclease G 10.1
SERPINB1 10.1
ELOVL4 10.0
Fibrillarin 10.0
CRN 10.0
deoxyribonuclease I 10.0
calcium-modulating cyclophilin ligand 9.9
ACCA 9.9
deoxyribonuclease 9.9
RhoGDI2 9.9
NBL 9.8
non-histone chromosomal protein 9.8
DNase I 9.8
PNR 9.6
elastase inhibitor 9.5
PPAR-beta 9.5
P49 9.5
DFF40 9.3
ETF 9.2
ATRIP 9.2
NLRX1 9.2
EKLF 8.9
ICAD 8.9
TREX1 8.9
phosphomonoesterase 8.9
histone protein 8.8
Nuclear protein 8.8
cathepsin C 8.7
MN1 8.6
DNA-dependent DNA polymerase 8.6
interferon receptor 8.6
chymotrypsin-like protease 8.6
RNA-associated 8.5
HMG2 8.5
AHS 8.4
arylsulphatase 8.4
cathepsin 8.4
L17 8.3
high mobility group protein 8.3
Poly(ADP-ribose) polymerase 8.2
cathepsin D 8.2
arylsulfatase 8.1
apoptosis-inducing factor 8.0
topoisomerase II alpha 7.9
novel transcript 7.9
endonuclease 7.9
AIM2 7.8
acid phosphatase 7.8
nucleotide pyrophosphatase 7.8
STING 7.8
HNE 7.8
Acid phosphatase 7.8
LAMP-2 7.8
IRF7 7.8
nm23-H1 7.8
phospholipid hydroperoxide glutathione peroxidase 7.8
GDI 7.7
hsp 70 7.7
G6PDH 7.6
SCAR 7.5
NOX1 7.5
RNase A 7.5
serine hydrolase 7.5
beta-glucuronidase 7.4
MF1 7.4
transcription factor IIIA 7.4
ADAR1 7.3
Caspase-1 7.3
PAI-2 7.3
vitamin D-binding protein 7.2
FKBP 7.2
PARP-1 7.2
A14 7.2
p28 7.2
NPD 7.1
TLR9 7.1
DNaseI 7.1
glutathione peroxidase 4 7.1
interferon-beta 7.0
RNase L 7.0
NPS 6.9
arylsulfatase A 6.9
CNPase 6.9
alpha-mannosidase 6.9
LOX-1 6.9
RIP1 6.8
MAVS 6.8
TLR7 6.8
TIMP-3 6.7
melastatin 6.7
photolyase 6.7
ISG15 6.7
N-acetyl-beta-glucosaminidase 6.7
linker histone 6.7
TLR8 6.6
APH 6.6
MEF 6.6
AIF 6.5
pyrophosphatase 6.5
DNA ligase 6.5
serine protease inhibitor 6.5
RNase 6.5
Gallus gallus 6.5
H10 6.5
arylesterase 6.5
CAD 6.4
PKC zeta 6.4
DNA polymerase alpha 6.3
H2B 6.3
EDA 6.3
HP1 6.3
LAMP 6.3
alpha-L-fucosidase 6.3
SP-A 6.3
glutamate pyruvate transaminase 6.2
calpain 6.2
p75NTR 6.2
TRIF 6.2
calpain inhibitor 6.2
E11 6.1
H2A 6.1
Apaf-1 6.1
LL-37 6.1
ribonuclease A 6.1
mannose 6-phosphate receptor 6.1
MMP-8 6.1
nm23 6.1
LDLR 6.1
TSK 6.0
RNase H 5.9
superoxide dismutase 1 5.9
IFN-beta 5.8
IRF3 5.8
Chk2 5.7
TdT 5.6
more...
Disease
Fowlpox 9.9
Oxygen toxicity 9.6
trichinellosis 8.4
MPE 7.3
hyperphenylalaninemia 6.9
polyarthritis 6.8
NPS 6.7
Fallopian tube 6.6
Still's disease 6.6
HP1 6.3
sarcoma 180 6.2
protein deficiency 6.1
LDLR 6.1
skin infection 5.8
EDA 5.2
worms 5.1
hookworm 5.1
AMD 5.1
ADH 5.1
T-cell acute lymphoblastic leukemia 4.9
PAA 4.9
vaccinia 4.8
Rous sarcoma 4.6
smallpox 4.5
lymphoblastic leukemia 4.3
myeloid leukemia 4.2
erythroleukemia 4.2
liver fibrosis 4.2
epididymis 4.2
CEM 4.1
Newcastle disease 3.9
primary biliary cirrhosis 3.9
neoplastic transformation 3.9
zoonosis 3.8
anemia 3.7
SDS 3.6
systemic lupus erythematosus 3.6
small cell lung cancer 3.5
nephritis 3.4
PCP 3.4
status epilepticus 3.4
leukopenia 3.3
Melanoma 3.3
lupus 3.3
acute promyelocytic leukemia 3.2
autoimmune disease 3.2
arthropathy 3.1
myocarditis 3.1
arthritis 3.1
PHA 3.1
stomatitis 3.1
coronary artery disease 3.0
Graves' disease 3.0
acute leukemia 3.0
dilated cardiomyopathy 3.0
Steroids 3.0
DBA 2.9
TEM 2.8
acute pancreatitis 2.8
TEM 2.8
lupus 2.7
myopathy 2.6
cystic fibrosis 2.6
tetanus 2.6
sarcoma 2.5
ATM 2.5
rheumatoid arthritis 2.5
fatty liver 2.4
herpes simplex 2.4
glomerulonephritis 2.4
Mycoplasma 2.3
ash 2.3
bacterial infection 2.3
fits 2.2
pancreatitis 2.2
virus infection 2.2
uterus 2.1
cerebral ischemia 2.1
GSH 2.0
cardiomyopathy 1.8
carcinogenesis 1.8
leukemia 1.7
sepsis 1.5
neuroblastoma 1.4
suicide 1.4
malnutrition 1.4
tumor growth 1.3
sepsis 1.3
ischemia 1.3
cold 1.3
liver disease 1.3
adenocarcinoma 1.1
melanoma 1.1
hepatocellular carcinoma 1.1
heart failure 1.0
multiple myeloma 1.0
lymphoma 1.0
carcinoma 1.0
atherosclerosis 0.9
tumor progression 0.9
multiple sclerosis 0.8
SEM 0.6
plaque 0.5
tumorigenesis 0.4
prostate cancer 0.3
tumor 0.3
epilepsy 0.2
cancer 0.0
metastases -0.5
Alzheimer's disease -0.6
obesity -0.8
hypertension -1.2
diabetes -1.9
Symptom
muscle cramps 7.4
DNA marker 6.3
cerebellar ataxia 4.4
splenomegaly 3.9
hyperoxia 3.8
acidity 3.3
starvation 3.2
tremor 2.0
collapse 1.4
seizures -0.1
anesthesia -0.6
Drug
CA-074 10.4
DNase I 9.7
Belimumab 9.6
Rasburicase 8.2
Papain 7.1
Amiloride 6.6
Amiloride 6.4
Lovastatin 5.8
IFN-beta 5.6
Docetaxel 5.4
DMI 5.1
PCP 4.3
ascorbate 3.7
ABC 3.1
nitroglycerin 3.1
lysine 2.9
Ethanol 2.9
Gel 2.3
MAP 2.2
ROS 1.9
caffeine 1.8
NADH 1.8
IL-2 1.3
Monit 1.1
Dermatol -0.8
Enzyme
DNase II 16.2
beta-glycerophosphatase 11.4
3'-exonuclease 10.5
deoxyribonuclease 10.4
deoxyribonuclease 10.4
DNase 10.0
micrococcal nuclease 9.7
Escherichia coli exonuclease III 9.3
exoribonuclease 9.0
venom phosphodiesterase 8.9
phosphatidylserine synthase 8.6
cathepsin C 8.6
cathepsin D 8.3
ADPase 8.1
p-nitrophenylphosphatase 7.9
acid phosphatase 7.9
endonuclease 7.9
phospholipid hydroperoxide glutathione peroxidase 7.7
RNase 7.6
beta-glucuronidase 7.5
arylsulfatase 7.5
alpha-L-fucosidase 7.2
alpha-mannosidase 7.2
neutrophil elastase 7.2
alpha-L-fucosidase 7.1
CNPase 7.1
ribonuclease 7.1
ribonuclease 7.1
RNase 7.0
hexosaminidase 7.0
uricase 6.9
S1 nuclease 6.9
arylsulfatase A 6.9
sulfatase 6.9
polynucleotide kinase 6.8
alpha-L-fucosidase 6.7
CAD 6.4
CAD 6.4
CAD 6.3
beta-glucosidase 6.3
beta-glucosidase 6.1
topoisomerase 5.9
heparinase 5.9
topoisomerase 5.8
beta-galactosidase 5.8
phosphodiesterase 5.8
DNA ligase 5.8
DNA ligase 5.8
RNase H 5.8
5'-nucleotidase 5.6
paraoxonase 5.4
TdT 5.3
thermolysin 5.3
PRE 5.3
cathepsin L 5.2
chondroitinase 5.2
cathepsin B 5.2
caspase-1 5.1
chondroitinase 5.1
cytochrome oxidase 5.1
ADH 5.1
PARP 5.0
elastase 5.0
CPR 4.8
sialidase 4.8
glucokinase 4.7
carboxylesterase 4.6
hyaluronidase 4.6
granzyme B 4.5
aldolase 4.4
chymotrypsin 4.3
PCP 4.3
phospholipase D 4.3
glucose-6-phosphate dehydrogenase 4.3
lactate dehydrogenase 4.2
alpha-glucosidase 4.1
DNA polymerase 4.1
subtilisin 4.1
citrate synthase 4.0
hyaluronidase 4.0
neuraminidase 3.9
invertase 3.9
DNA methyltransferase 3.9
chloramphenicol acetyltransferase 3.9
caspase-3 3.9
lysozyme 3.8
diaphorase 3.7
alkaline phosphatase 3.6
papain 3.5
trypsin 3.4
phospholipase A2 3.4
xanthine oxidase 3.1
pepsin 3.1
RNA polymerase 3.1
catalase 3.0
alcohol dehydrogenase 3.0
lipase 3.0
luciferase 3.0
NADPH oxidase 2.9
monoamine oxidase 2.8
NADPH oxidase 2.7
calcineurin 2.1
collagenase 2.0
aspartate aminotransferase 1.8
ATPase 1.8
glutathione S-transferase 1.7
alanine aminotransferase 1.5
reverse transcriptase 1.2
focal adhesion kinase 0.8
protein kinase C 0.6
ERK -0.4
mitogen-activated protein kinase -0.4
Compound
1-naphthyl butyrate 12.9
Chlorozotocin 11.1
Methyl green 11.0
20-Hydroxyecdysone 10.0
EDAP 8.7
Mithramycin 8.5
MPE 8.2
Inosine 8.1
Leupeptin 8.0
NMN 8.0
MgCl2 7.9
Leupeptin 7.7
Ribose 7.7
Triton WR-1339 7.6
DOPE 7.6
PHE 7.5
EHDP 7.5
Iodo 7.4
dGMP 7.1
APH 7.0
2-phenylethylamine 6.9
Lovastatin 6.7
Amiloride 6.6
PAM 6.6
PAM 6.6
DTT 6.2
Collagenase 6.2
T 1 6.2
DTT 6.1
4-AP 6.1
ACI 6.0
Hoechst 33342 6.0
AAF 5.8
GGG 5.8
MPA 5.8
MPA 5.8
Docetaxel 5.8
dGTP 5.7
Cortisol 5.7
DAMP 5.7
MPA 5.7
ADP-ribose 5.7
Mg2+ 5.6
C2H2 5.4
Carbachol 5.3
Chloroquine 5.3
Chloroquine 5.3
CCC 5.3
CCC 5.3
dUTP 5.3
Cytochrome c 5.2
THE 5.2
PPi 5.2
CPA 5.2
hexadecane 5.1
TAR 5.1
4-nitrophenyl 5.1
DMI 5.1
DMI 5.1
EDTA 5.1
EDTA 5.1
MIA 5.0
T10 5.0
HEPES 4.9
DEAE 4.9
Triton X-100 4.9
PAR 4.9
PAA 4.9
BLM 4.7
Ascorbic acid 4.7
TMP 4.7
A 42 4.7
DNA 4.6
MCA 4.6
CTAB 4.6
MCA 4.6
VP-16 4.5
acrylamide 4.4
DNP 4.4
glucose-6-phosphate 4.4
Heme 4.4
2-mercaptoethanol 4.2
Triton 4.1
sulfuric acid 4.1
PCP 4.1
stearic acid 4.1
stearic acid 4.1
Tris 4.0
Chitosan 4.0
2-hydroxyethyl 4.0
2-hydroxyethyl 4.0
2-hydroxyethyl 4.0
2-hydroxyethyl 4.0
2-hydroxyethyl 4.0
2-hydroxyethyl 4.0
2-hydroxyethyl 4.0
GMP 4.0
stearic acid 4.0
Methotrexate 3.9
Tris 3.8
THP 3.8
THP 3.8
KOH 3.8
2-hydroxyethyl 3.7
Retinal 3.6
pentose 3.6
pentose 3.6
adenylate 3.6
COS 3.6
ADP 3.6
ADP 3.5
pentose 3.5
BCR 3.5
Melatonin 3.5
pyrimidine 3.5
SDS 3.5
pentose 3.5
pyrimidine 3.4
ADP 3.4
bromide 3.4
6-12 3.4
serine 3.3
DDP 3.3
formaldehyde 3.2
Phytol 3.2
Phytol 3.2
aniline 3.2
Progesterone 3.1
alcohol dehydrogenase 3.1
Adrenal 3.1
sulfate 3.1
salt 3.1
zinc 3.1
TCA 3.1
BCG 3.0
DBA 3.0
ammonium 3.0
guanidine 3.0
DBA 3.0
MAP 3.0
aldehyde 3.0
Estrogen 3.0
phosphate 2.9
formaldehyde 2.9
pyrene 2.9
TOF 2.9
CAM 2.8
Estrogen 2.8
anthracene 2.8
acetate 2.8
urea 2.8
N-acetylcysteine 2.8
salicylic acid 2.7
DBA 2.7
Asp 2.7
TEM 2.6
aldehyde 2.6
His 2.5
NAD 2.5
phenol 2.5
more...