Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.22.1 (
DNase II
)
429
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
LEI/L-
DNase II
is the key protein of a caspase-independent pathway activated by serine proteases. LEI (
Leukocyte elastase inhibitor
), L-
DNase II
precursor, is a member of the clade B serpins (also called serpin b1). In its native conformation it inhibits several intracellular proteases and has an anti-apoptotic activity. Following a metabolic stress and the increase of protease activity in the cell, LEI is cleaved and transformed into L-
DNase II
(LEI-derived
DNase II
). This transformation is due to a conformational modification that exposes a nuclear localization signal and an endonuclease active site. In this paper we show that LEI can bind the exportin Crm1, and we identify on LEI a nuclear export signal involved in the control of LEI/L-
DNase II
nuclearization in healthy cells. Point mutation of this site increases the accumulation of the molecule in the nucleus and triggers cell death.
...
PMID:Nuclear export of LEI/L-DNase II by Crm1 is essential for cell survival. 1834 33
