Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.21.3 (
deoxyribonuclease
)
1,528
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Parapneumonic effusions are seen in up to 57% of patients with pneumonia. The majority of these effusions are noninfected and resolve with standard antibiotic treatment for the associated pneumonia. However, parapneumonic effusions in a minority of cases become infected and require prompt chest tube drainage and occasionally thoracic surgery. Patients may present in a variety of ways from florid sepsis to weight loss and
anorexia
; such diversity mandates a high index of suspicion among physicians. The role of the combination of intrapleural
deoxyribonuclease
(
DNase
) and tissue plasminogen activator (t-PA) to aid fluid drainage shows promise but needs further assessment in large trials with surgery and mortality as primary end points.
...
PMID:The approach to the patient with a parapneumonic effusion. 2121 2
