Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.21.1 (
DNase
)
7,655
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The presence is reported of an RNA-instructed DNA polymerase in visna virus, the causative agent of a "slow" neurological disease in sheep. The product synthesized by the RNA-directed reaction has been shown to be a DNA heteropolymer by the following criteria: synthesis requires the presence of all four deoxyriboside triphosphates; the product is resistant to ribonuclease and alkali but is degraded by
DNase
; and the product has a density of 1.420 in Cs(2)SO(4) solution, characteristic of DNA.
Visna
virions, like those of the oncogenic RNA viruses, contain DNA polymerase activities that respond to a variety of double-stranded DNAs and to synthetic DNA.RNA hybrids.
...
PMID:DNA polymerase activities in varions of visna virus, a causative agent of a "slow" neurological disease. 499 14
