Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.13.1 (exoribonuclease)
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Human Gene/Protein
EXOSC10 protein 15.4
mpp6 15.4
C19orf43 15.4
LOC81691 15.4
hPan3 14.4
PNPase 13.9
DIS3L 13.8
MPP6 13.7
DIS3L2 13.7
Rrp4p 13.6
EXOSC10 13.5
polynucleotide phosphorylase 13.4
hRrp42p 13.4
SKI1 13.4
ISG20L2 13.4
XRN2 13.3
SKI2 13.3
DEDD 13.2
XRN1 13.2
CNOT10 13.1
RRP44 13.1
ARM-repeat protein 13.1
Mtr3p 13.1
DOM3Z 13.1
DIS3 13.1
3' exoribonuclease 13.0
SUV3 12.9
ISG20 12.9
SKI8 12.9
exoribonuclease 2 12.8
GTPBP1 12.8
XPMC2 12.8
Rrp43p 12.7
STK19 12.6
USP52 12.6
RNA helicase) 12.6
CBC2 12.4
BPntase 12.4
Rrp6p 12.4
RNase E 12.3
Rrp40p 12.2
TTC4 12.1
ribosomal protein S15 11.9
PM/Scl-75 11.9
GCD10 11.8
DSS1 11.8
CCR4-associated factor 1 11.7
mut-7 11.7
ROK1 11.5
PELO 11.5
Collaborator of ARF 11.4
TRF4 11.4
Endoribonuclease 11.4
P12A 11.3
Mtr4 11.3
ribosomal protein S20 11.3
RNR 11.3
PAN2 11.2
HEM45 11.2
2'-phosphodiesterase 11.1
NMD3 11.1
cytoplasmic deadenylase 11.1
C16orf57 11.0
CLC-5 10.9
interferon alpha/beta receptor 10.9
GPX7 10.9
Rpp14 10.9
CML28 10.8
PARN 10.8
tRNase Z 10.8
NKRF 10.8
CNOT6L 10.8
NELF-E 10.7
putative RNA helicase 10.7
deoxyribonuclease II 10.6
poly(A)-specific ribonuclease 10.6
TNRC6B 10.5
goa 10.5
SEP1 10.5
CLEC14A 10.4
SKIV2L 10.4
LSM2 10.3
TRM6 10.3
UPF3 10.3
TUTase 10.3
SLBP 10.2
LARP1 10.1
UBE2A 10.1
stem-loop binding protein 10.0
REG1 9.9
EF-1a 9.9
C1D 9.9
CAF1 9.9
RING1B 9.8
RNA helicase 9.8
CBP1 9.7
PRT1 9.7
decapping enzyme 9.7
Smaug 9.7
IFIT5 9.7
RNR1 9.7
LSM1 9.6
CARF 9.6
RNase III 9.6
SAL1 9.6
PAB1 9.6
Exportin-5 9.5
GLD-2 9.5
DCP2 9.4
GE1 9.4
NIFL 9.4
PM-Scl 9.4
PDE11A 9.4
HEN1 9.3
RNase 9.3
exonuclease 1 9.2
maelstrom 9.2
RAI1 9.2
TRAMP 9.2
CRV 9.2
SSD1 9.2
retinoic acid-inducible gene 1 9.1
SKI 9.1
HBS1L 9.0
ATP-dependent RNA helicase 9.0
UPF2 8.9
PDE2A 8.9
Ro60 8.9
COB 8.8
Argonaute-2 8.8
RNA-associated 8.7
PPAR-beta 8.7
IMP3 8.7
RNase A 8.7
CSD 8.7
DNase II 8.7
DEAD-box RNA helicase 8.7
nucleic acid-binding protein 8.6
DHH 8.6
RTEL1 8.4
CCA 8.4
TCL1 8.4
RNase H1 8.4
MRP-1 8.4
erk 8.3
BFP 8.3
coilin 8.3
E-like 8.3
PAT1 8.2
thyroid hormone responsive 8.2
AGO1 8.2
UPF1 8.2
E.coli) 8.2
cleavage and polyadenylation specificity factor 8.1
DDX5 8.1
NAB2 8.1
NRF 8.1
TREX1 8.1
RNA-dependent ATPase 8.1
proSAAS 8.1
PDE3B 8.1
3'-5' exonuclease 8.0
TIM23 8.0
PRI 8.0
ribosomal protein S12 8.0
XMP 8.0
MME 8.0
P250 7.9
Exonuclease III 7.9
C.elegans 7.9
pp120 7.9
L24 7.9
ubiquitin conjugating enzyme 7.9
Calnexin 7.9
DNA-dependent DNA polymerase 7.9
RNA-directed DNA polymerase 7.8
COIII 7.8
PDE4A 7.8
DEAD 7.8
synexin 7.8
survival of motor neuron 7.8
OUT 7.8
mitochondrial RNA polymerase 7.7
Ankyrin 7.7
RP1 7.7
PH2 7.7
CIR 7.7
CCR4-NOT 7.7
yeast homolog 7.7
LIN28 7.6
Phosphorylase 7.6
CASP 7.6
TRIM25 7.6
THO 7.6
EBF1 7.6
GW182 7.5
Y14 7.5
enolase 7.5
CBP80 7.5
L14 7.4
PIWI 7.4
EMB 7.4
ribonuclease P 7.4
small nuclear ribonucleoprotein particle 7.4
ATP binding cassette transporter 7.4
G20 7.3
PAP 7.3
helicase 7.3
cyclin T1 7.3
anchor protein 7.2
H4 histone 7.2
IFIH1 7.2
Ribonuclease 7.2
TFIIIB 7.2
c-myc mRNA 7.1
DGCR8 7.1
phosphomonoesterase 7.1
glycolytic enzyme 7.0
poly(A)-binding protein 7.0
DAN 7.0
NONO 7.0
interferon regulatory factor-1 7.0
snRNP 7.0
SAMHD1 6.9
centrin 6.9
Enolase 6.9
Myc protein 6.9
transcription elongation factor 6.9
PIN 6.9
cyclin-dependent kinase inhibitor p27 6.8
Werner syndrome 6.8
Ro52 6.8
corneal dystrophy 6.8
p27(KIP1) 6.8
CFB 6.7
Ly49 6.7
bcl-x 6.7
RNA-binding protein 6.6
dynamin 2 6.6
RISC 6.6
ND3 6.6
tailless 6.5
DSS 6.5
G11 6.5
p185 6.5
apoptosis inhibitor 6.5
IFNAR 6.4
DCS 6.4
NOC 6.4
M14 6.4
CYP17A1 6.3
C. elegans) 6.3
NTP 6.3
non-catalytic 6.3
Nucleophosmin 6.3
tRNA 6.3
CCAAT/enhancer-binding protein homologous protein 6.3
NL4 6.3
methyltransferase 6.3
CCR4 6.2
RNase L 6.2
methylmalonyl-CoA mutase 6.2
endonuclease 6.2
MRP 6.2
galactokinase 6.1
SR protein 6.1
arginine methyltransferase 6.1
inorganic pyrophosphatase 6.1
cytochrome oxidase subunit I 6.0
PNP 6.0
ribosomal protein 6.0
interacting protein 1 6.0
autoantigen 6.0
RNA recognition motif 6.0
TIMP-3 6.0
elongation factor G 6.0
CLIP 5.9
type I interferon 5.9
eIF4E 5.9
multidrug resistance protein 5.8
RIG-I 5.8
eukaryotic translation initiation factor 5.8
NOT 5.8
Dicer 5.7
MSV 5.7
DOM 5.7
aconitase 5.7
RNP 5.7
RNase H 5.7
interferon-beta 5.7
CBF1 5.6
GAL1 5.6
Era 5.6
Poly 5.6
small nuclear ribonucleoprotein 5.6
XBP1 5.6
VCP 5.6
GMP 5.5
nucleotide pyrophosphatase 5.5
HuR 5.5
ribonucleoprotein 5.5
Chlamydomonas 5.4
EF-Tu 5.4
5'-nucleotidase 5.4
thymidylate synthetase 5.4
FMRP 5.4
cyclic AMP phosphodiesterase 5.4
RNA polymerase II 5.4
HDAC2 5.4
ribonuclease A 5.3
hnRNP 5.3
JUN 5.3
DMD 5.3
podoplanin 5.2
signal recognition particle 5.2
SARS 5.2
programmed death ligand 1 5.2
E2A 5.1
TPR 5.1
alpha-mannosidase 5.1
more...
Disease
Perlman syndrome 12.9
XRN 12.5
ACCCA 11.8
poikiloderma 9.2
Lassa fever 8.0
RP1 7.7
PIN 7.1
DSS 6.5
PIN 6.2
DSS 6.2
dyskeratosis congenita 5.9
SARS 5.8
pseudotuberculosis 5.7
myeloblastosis 5.5
Shigella flexneri 5.4
Yersinia 5.0
Rift Valley fever 4.9
polymyositis 4.7
premature aging 4.3
PDE 4.1
WT1 4.0
CDS 3.9
scleroderma 3.9
PCC 3.9
hepatitis 3.8
AAA 3.8
Brucella abortus 3.8
Shigella 3.8
cold 3.7
Japanese encephalitis 3.7
yellow fever 3.6
dengue 3.5
Dissociation 3.5
erythroleukemia 3.4
CEM 3.4
neutropenia 3.3
retinitis pigmentosa 3.1
Syndrome 3.0
idiopathic pulmonary fibrosis 3.0
metastatic melanoma 2.8
PDB 2.7
Legionella 2.6
pulmonary fibrosis 2.6
Lyme disease 2.6
pheochromocytoma 2.6
Mycoplasma 2.6
Duchenne muscular dystrophy 2.5
muscular atrophy 2.4
developmental delay 2.4
epididymis 2.4
abdominal aortic aneurysm 2.3
melanoma 2.3
Blocking 2.3
amyotrophic lateral sclerosis 2.2
virus infection 2.2
cholera 2.1
vaccinia 2.0
PSS 2.0
malaria 2.0
gastroenteritis 1.9
liver cancer 1.9
multiple myeloma 1.9
skin disease 1.8
Infection 1.8
ATM 1.7
cytomegalovirus 1.6
tumorigenesis 1.6
systemic lupus erythematosus 1.6
liver cancer 1.5
SDS 1.4
acute myeloid leukemia 1.3
Best 1.3
hepatitis B 1.2
tumor progression 1.1
pancreatic cancer 1.1
non-small cell lung cancer 0.9
leukemia 0.9
autoimmune disease 0.8
tuberculosis 0.8
sarcoma 0.7
Mycobacterium 0.7
neuroblastoma 0.6
infectious diseases 0.6
prostate cancer 0.6
uterus 0.4
hepatitis C 0.4
hepatocellular carcinoma 0.3
West 0.2
HIV 0.0
plaque -0.3
cancer -0.4
influenza -0.4
schizophrenia -0.5
carcinogenesis -0.6
immunodeficiency -0.7
tumor -0.8
atherosclerosis -0.8
Alzheimer's disease -1.3
diabetes -1.7
carcinoma -1.8
breast cancer -1.9
Symptom
starvation 4.6
exhaustion 1.7
collapse 0.6
Drug
EMB 7.4
Alanine 5.5
FLP 5.3
IFN-beta 4.8
Glycerol 4.2
Alliance 4.0
Ethanol 3.2
ROC 2.5
DNase I 2.4
lysine 0.6
Enzyme
exoribonuclease 15.4
oligoribonuclease 13.8
RNase D 13.5
polynucleotide phosphorylase 13.5
RNase PH 12.8
poly(A)-specific ribonuclease 11.7
poly(A)-specific ribonuclease 11.1
poly(A) polymerase 11.0
purine nucleoside phosphorylase 10.8
TUT 10.7
tRNase Z 10.7
exodeoxyribonuclease 10.7
i-AAA protease 10.6
RNase III 10.3
RNase 9.7
CobB 9.5
DNase II 9.0
RNase 9.0
3'-exonuclease 8.8
ribonuclease 8.7
ribonuclease 8.6
exonuclease I 8.6
eEF2 kinase 8.5
RNase P 8.2
RNA ligase 8.0
3'-phosphatase 8.0
lysine acetyltransferase 7.9
RNase T1 7.7
HC-Pro 7.7
lambda exonuclease 7.7
uridyltransferase 7.7
polyphosphate kinase 7.6
enolase 7.5
nucleotidase 7.4
LuxS 7.2
penicillin acylase 7.1
inositol phosphatase 7.0
venom phosphodiesterase 6.6
endonuclease 6.2
S1 nuclease 6.2
galactokinase 6.1
tryptophan synthase 6.0
RNase H 6.0
fatty acid desaturase 6.0
aconitase 5.6
Rex 5.5
5'-nucleotidase 5.4
transcriptase 5.2
RNA polymerase 5.0
micrococcal nuclease 4.9
deoxyribonuclease 4.9
alpha-mannosidase 4.8
deoxyribonuclease 4.8
thymidylate synthase 4.6
MPP 4.5
cathepsin D 4.4
phosphodiesterase 4.4
DNA polymerase 4.4
acid phosphatase 4.3
DNase 4.1
DNA ligase 4.0
DNA ligase 4.0
ATP synthase 3.6
hexosaminidase 3.6
PDE 3.6
phosphofructokinase 3.5
proteinase K 3.4
glutamine synthetase 3.1
chloramphenicol acetyltransferase 3.1
phosphorylase 3.0
ATPase 2.7
proteasome 2.6
beta-glucuronidase 2.5
glucose-6-phosphate dehydrogenase 2.5
reverse transcriptase 2.5
alkaline phosphatase 2.4
succinate dehydrogenase 2.4
complex I 2.3
glutathione S-transferase 1.9
beta-lactamase 1.7
phospholipase A2 1.6
beta-galactosidase 1.6
luciferase 1.2
adenylate cyclase 1.2
protein kinase 1.1
lactate dehydrogenase 0.6
trypsin 0.0
focal adhesion kinase -0.0
mitogen-activated protein kinase -1.1
Compound
Hygromycin B 9.2
D 3 8.9
8-hydroxyguanosine 8.8
dADP 8.4
XMP 8.1
3'-AMP 7.9
PAP 7.3
methylguanosine 7.2
Hypericin 7.2
PH2 7.2
PAP 7.1
PAP 7.1
PAP 7.0
MME 7.0
PIN 6.8
Uridine 6.8
40S 6.8
G20 6.7
Baicalein 6.5
G11 6.5
N-hydroxysuccinimide ester 6.3
Isoform 6.2
Guo 6.0
DOP 5.8
DSS 5.7
Alanine 5.6
adenylate 5.6
uridine 5.5
PPi 5.4
Bromocriptine 5.3
Emodin 5.3
UMP 5.3
DMD 5.3
PAN 5.1
TMP 4.9
PNP 4.9
MMA 4.7
Casein 4.7
GMP 4.6
CCC 4.5
CCC 4.5
TMP 4.5
Mg2+ 4.4
TMP 4.4
TMP 4.4
TAR 4.4
Ethylene 4.1
CIT 4.0
AAA 3.9
DEHP 3.9
CTP 3.8
Guo 3.8
acrylonitrile 3.8
DNP 3.7
PDB 3.5
A 3 3.5
PAM 3.5
PAM 3.5
pyrimidine 3.4
pyrimidine 3.4
Triton 3.4
AMP 3.2
Histone 3.2
MgCl2 3.2
phosphate 3.1
manganese 3.1
DEAE 3.1
ADP-ribose 2.9
hexose 2.9
hexose 2.9
hexose 2.9
Yellow 2.8
Adenosine 2.7
tryptophan 2.6
ATP 2.6
tryptophan 2.6
tryptophan 2.6
6-12 2.6
tryptophan 2.6
tungsten 2.6
GTP 2.6
adenosylmethionine 2.4
Salt 2.3
hexose 2.3
alanine 2.3
Tris 2.3
PEG 2.2
glycerol 2.1
Tris 2.1
DNA 2.1
NADP 1.9
Neuronal 1.9
Asp 1.9
asparagine 1.9
ADP 1.8
ADP 1.8
zinc 1.8
His 1.7
glutamine 1.7
EDTA 1.7
EDTA 1.7
PEG 1.6
ADP 1.6
methionine 1.6
H2O2 1.5
Thyroid 1.5
barium 1.4
serine 1.4
acrylamide 1.4
SDS 1.3
toluene 1.2
sulfate 1.2
arginine 1.2
lysine 1.1
threonine 1.0
NH2 0.9
nickel 0.5
ammonium 0.5
proline 0.4
Gly 0.3
hydrogen 0.3
iron 0.3
cadmium 0.3
Dec 0.1
sodium -0.1
phosphorus -0.1
tyrosine -0.2
glucose -0.2
Phe -0.2
salt -0.4
oxygen -0.5
urea -0.6
ethanol -0.7
glutamate -0.7
cysteine -0.8
calcium -0.9
CO2 -1.1
copper -1.1
nitric oxide -1.2
acetate -1.4
nitrogen -1.9
water -4.0
Clin -5.2