Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
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Human Gene/Protein
acetylcholinesterase isoform E4-E6 precursor 11.3
Rho GTPase-activating protein 4 11.3
butyrylcholinesterase 11.3
pseudocholinesterase 11.1
CHE1 10.6
Cholinesterase 10.4
RIC8 10.3
major facilitator superfamily domain containing 1 10.3
leiomodin 2 10.3
RING finger protein 121 10.3
macoilin 9.3
RIC-3 9.3
TEPP 9.0
Carboxylesterase 9.0
AChE 8.9
CHED 8.8
ENaCbeta 8.7
COLQ 8.7
acetylcholinesterase 8.7
ACHE 8.5
lipocalin-1 interacting membrane receptor 8.5
phosphodiesterase 9A 8.5
PLEKHB1 8.5
ABHD10 8.5
RAB11B 8.5
neuropathy target esterase 8.5
carboxylesterase 8.3
cholinesterase-related cell division controller 8.3
CTL3 8.3
APBB1 8.2
APH1A 8.1
ADAS 8.1
lamellipodin 8.0
dipeptidyl peptidase 9 8.0
ALG14 8.0
choline acetylase 8.0
arylformamidase 7.8
NCAD 7.8
OTOG 7.8
QN1 7.8
phosphorylase, glycogen 7.8
PRIMA 7.7
ALG13 7.7
MADA 7.7
arylesterase 7.6
paraoxonase 7.5
phosphoglucomutase 2 7.5
Munc-18-3 7.5
T. californica 7.5
CHCHD3 7.4
FIF 7.3
AK5 7.3
Alpha-L-fucosidase 7.3
SLC5A7 7.2
MTND1 7.2
Succinic dehydrogenase 7.1
serine hydrolase 7.0
choline transporter 7.0
CHRNA 7.0
aquaporin 7 7.0
NTE 6.9
CHRNE 6.9
NDUFAF2 6.9
muscarinic acetylcholine receptor M3 6.9
RIC-8 6.9
cholesteryl ester hydrolase 6.8
receptor for advanced glycosylation end products 6.8
pancreatic cholesterol esterase 6.8
Midori 6.8
BACE 6.8
NIMP 6.8
AP-B 6.8
NLGN3 6.7
CTL1 6.7
Paraoxonase 6.7
CRHBP 6.6
MNGIE 6.6
SESN3 6.6
PON1 6.6
PN1 6.6
more...
Disease
Butyrylcholinesterase deficiency 11.3
Specific disorders of sleep 11.3
Impairment of attention 11.3
Pseudocholinesterase deficiency 10.9
Prolonged neuromuscular block 10.7
Cholinergic crisis 10.6
Acute cholestatic hepatitis 10.3
Thyrotoxic myopathy 10.3
BD syndrome 9.7
urination disorder 9.3
Intercurrent disease 9.0
Bronchopulmonary infection 8.7
CHED 8.7
Subcortical vascular dementia 8.7
Alzheimer's disease with early onset 8.5
Distal spinal muscular atrophy 8.5
Sundowning 8.5
GSM1 8.3
FIF 8.3
Macronodular cirrhosis 8.0
Upbeat nystagmus 8.0
Pisa syndrome 7.9
BPSD 7.9
Dementia in Parkinson's disease 7.8
Congenital Myasthenic Syndromes 7.8
Acute glaucoma 7.6
CLAM 7.5
FRA16A 7.5
Neuronal intestinal dysplasia 7.5
Gulf War Syndrome 7.1
Sleep attacks 7.0
Enzyme inhibition 7.0
Neuromuscular blockade 6.9
MNGIE 6.6
Vascular dementia 6.6
disturbed memory 6.6
Type V hyperlipoproteinemia 6.6
bronchorrhea 6.6
Xanthinuria 6.5
Ocular myasthenia 6.4
Tuberculoid leprosy 6.4
Dementia with Lewy bodies 6.4
myasthenia 6.4
Frohlich 6.3
thymic neoplasm 6.3
Bowel dysfunction 6.2
Neuromuscular blockade 6.2
calorie deficiency 6.1
Opsoclonus 6.1
GALE 6.0
Mandibuloacral dysplasia 6.0
Ciliary body 6.0
Ciliary body 6.0
parasympathomimetic 6.0
insect disease 6.0
JWS 5.9
Autonomic imbalance 5.9
Witts 5.9
angiectasis 5.8
noninvasive thymoma 5.8
myasthenia gravis 5.8
Vocal cord paralysis 5.7
Alzheimer's disease 5.7
Bovine babesiosis 5.7
gastric mucosal atrophy 5.6
senile dementia 5.5
impaired judgment 5.5
cocaine abuse 5.5
heroin abuse 5.5
type AB thymoma 5.5
catatonic schizophrenia 5.4
hallucinosis 5.4
Ogilvie's syndrome 5.3
cocaine addiction 5.3
cholestatic cirrhosis 5.2
Bone marrow depression 5.2
IBR 5.2
memory impairment 5.2
dementia 5.1
EDIM 5.1
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Symptom
Slight fever 11.3
Moist rales 10.3
Antecollis 8.5
ACHE 8.0
Local swelling 7.6
visual hallucination 6.6
redness of the eyes 6.5
Behavioral symptoms 6.5
urological problem 6.4
fasciculation 5.5
frequent urination 5.5
memory loss 5.1
Positive and Negative Symptoms 4.7
apathy 4.3
abdominal cramps 4.2
loss of equilibrium 4.2
leg cramps 4.1
hypalgesia 3.8
Decreased activity 3.8
muscle cramps 3.8
prostration 3.8
blurred vision 3.7
hypoproteinemia 3.7
agitation 3.7
Extrapyramidal symptoms 3.7
giddiness 3.6
giddiness 3.6
Involuntary Movement 3.6
tonic seizure 3.6
twitching 3.5
Multimorbidity 3.4
skin irritation 3.4
aphonia 3.3
rundown 3.3
chest tightness 3.3
lightheadedness 3.3
hyperesthesia 3.2
body pain 3.2
consciousness disturbance 3.2
dark urine 3.2
rhinorrhea 3.1
weakness 3.1
excessive sweating 3.1
Gastrointestinal symptoms 3.1
incoordination 3.1
Burning 3.1
rales 3.0
dizziness 3.0
tremor 2.9
emaciation 2.8
muscle rigidity 2.8
loss of taste 2.8
eye pain 2.7
bradykinesia 2.7
hypothermia 2.6
ataxia 2.5
nausea 2.5
Spots 2.5
acute stress 2.4
motor symptom 2.4
dry skin 2.3
anesthesia 2.3
asthenia 2.2
eds 2.2
Hudson 2.2
despair 2.2
sinus pressure 2.2
Postoperative pain 2.2
vomiting 2.2
ataxic gait 2.2
ketonuria 2.2
ophthalmoplegia 2.2
personality change 2.2
mental fatigue 2.1
Fluctuation 2.1
seizures 2.0
lethargy 2.0
nausea and vomiting 2.0
chronic constipation 2.0
tonic-clonic seizure 1.9
more...
Drug
Protopam Chloride 11.3
Butyrylthiocholine 11.3
Doxacurium chloride 10.7
Distigmine bromide 10.5
Phospholine Iodide 10.0
Exelon 9.8
Exelon 9.7
Pralidoxime 9.6
Pyridostigmine bromide 9.6
Mestinon 9.5
Mivacron 9.4
Donepezil 9.4
Reminyl 9.3
Aricept 9.3
Echothiophate iodide 9.3
Galanthamine 9.1
Cognex 9.0
Mivacron 9.0
Vanoxerine 9.0
Pyridostigmine bromide 8.8
Edrophonium chloride 8.7
Galantamine hydrobromide 8.6
Sugammadex sodium 8.5
Cyclogyl 8.5
Azilect 8.3
Physostigmine salicylate 8.2
Namenda 8.2
Eserine sulfate 8.1
Cyclogyl 8.1
Malotilate 8.1
Parbendazole 8.0
Prostigmin 8.0
DFP 7.9
Methscopolamine 7.8
Landiolol hydrochloride 7.8
Atracurium besylate 7.6
CXN 7.6
Gluthathione 7.6
2,4,6-Tribromophenol 7.5
THA 7.3
Brij 96 7.3
Quinidine sulfate 7.3
Clorsulon 7.3
EDR 7.3
Sulfamide 7.2
Propanidid 7.1
Rocuronium 6.9
Eucerin 6.8
Arfonad 6.8
Imidan 6.7
Oxybuprocaine 6.6
Phenoxymethylpenicillin 6.6
Cevimeline 6.6
Rokitamycin 6.6
DMAA 6.5
Hypnomidate 6.5
Ciclesonide 6.4
Loxiglumide 6.4
Arfonad 6.3
Atropine 6.2
Dibenzyline 6.2
Diastase 6.2
Ceruletide 6.2
Morphine hydrochloride 6.2
Scopolamine 6.2
Arduan 6.0
Propentofylline 6.0
Talwin 5.9
Antivenin 5.8
Darifenacin 5.7
Cardizem CD 5.7
Allegra 5.6
DDF 5.6
Allegra 5.6
Compound 16 5.6
Rasagiline 5.6
Gallamine 5.6
Aluminum chloride 5.5
Lercanidipine 5.4
Idebenone 5.4
more...
Enzyme
cholinesterase 11.3
acetylcholinesterase 9.9
aspirin esterase 9.9
AAA-1 8.5
atropine esterase 8.1
DFPase 8.1
carboxylesterase 7.8
carboxypeptidase 1 7.7
paraoxonase 7.7
choline oxidase 7.6
EC 3.1.1.47 7.6
paraoxonase 7.2
EC 1.1.1.38 6.8
acetylesterase 6.7
neuropathy target esterase 6.7
choline acetyltransferase 6.3
esterase D 5.9
kynurenine formamidase 5.9
prolyl endopeptidase 5.7
beta-secretase 5.7
monoacylglycerol lipase 5.6
leucine aminopeptidase 5.6
trimetaphosphatase 5.5
serum carnosinase 5.5
histidase 5.4
cholesterol esterase 5.4
monoamine oxidase 5.3
sorbitol dehydrogenase 5.2
succinic dehydrogenase 5.2
PAM 5.1
gamma-glutamyl transpeptidase 5.0
tyrosinase 5.0
octopine dehydrogenase 5.0
guanase 5.0
choline dehydrogenase 5.0
adamalysin 5.0
NADPH:quinone oxidoreductase 5.0
alanine aminopeptidase 4.9
bleomycin hydrolase 4.9
arylsulfate sulfotransferase 4.9
prolidase 4.9
NMT 4.9
p-hydroxybenzoate hydroxylase 4.9
carnitine acetyltransferase 4.9
SsuE 4.7
phosphatidylinositol phospholipase C 4.7
GCA 4.7
aspartate aminotransferase 4.6
alanine aminotransferase 4.6
alpha-lytic protease 4.5
glutamic dehydrogenase 4.5
delta-aminolevulinic acid dehydratase 4.4
DSR 4.4
carnosinase 4.4
beta-hydroxybutyrate dehydrogenase 4.3
glutamate dehydrogenase 4.3
nucleotidase 4.3
glutamate dehydrogenase 4.3
glutamate dehydrogenase 4.3
PWD 4.2
aldolase 4.2
phosphoglucomutase 4.2
prolinase 4.2
AST 4.1
lactate dehydrogenase 4.1
CGT 4.1
carbonic anhydrase 4.1
lactonase 4.0
acid phosphatase 4.0
deaminase 4.0
p-hydroxybenzoate hydroxylase 4.0
MDH 4.0
adenosine deaminase 3.9
adenosine deaminase 3.9
alkaline phosphatase 3.9
MDH 3.9
lecithin:cholesterol acyltransferase 3.9
CAO 3.9
thiopurine methyltransferase 3.8
histamine N-methyltransferase 3.8
more...
Compound
C13H18N2O2 11.3
Butyrylcholine iodide 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C28H34N2O6 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
Belladine 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
1-Dimethylaminonaphthalene 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C28H34N2O6 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
Isoterchebin 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C28H34N2O6 11.3
Isoxathion 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
F 2268 11.3
Fyrol 6 11.3
C13H18N2O2 11.3
Bis(trichloromethyl) sulfone 11.3
OMPA 10.7
2-butenediamide 10.7
5,6-dichloronicotinic acid 10.7
ethyl methylcarbamate 10.4
Echothiophate 10.4
Mivacurium 10.4
Phosphemide 10.3
C13H18N2O2 10.3
Hycanthone methanesulfonate 10.3
Nicoline 10.3
C14H14O2 10.3
phosphorofluoridic acid 10.3
C8H17NO2 10.3
C21H23NO5 10.3
Ambenonium 10.3
4-(methylsulfonyl)benzaldehyde 10.3
2,2-dimethylaziridine 10.3
gamma-Fagarine 10.3
AB-132 10.3
2-phenylacetohydrazide 10.3
C19H15NO2 10.3
C14H24O2 10.3
1,22-docosanediol 10.3
C13H11NO2 10.3
C13H18N2O2 10.3
AB 100 10.3
2-phenylacetohydrazide 10.3
Butyrylthiocholine iodide 10.3
Butyl disulfide 10.3
phosphorofluoridic acid 10.3
Rivastigmine 10.3
Bromophos 10.1
C13H18N2O2 9.7
TMB-4 9.7
vobtusine 9.7
Piperazine adipate 9.7
C13H18N2O2 9.7
Caffeoyl quinic acid 9.7
dimethylsulfamoyl chloride 9.7
Pteryxin 9.7
3,4-dimethoxybenzamide 9.7
C13H18N2O2 9.7
Gypsogenin 9.7
Pralidoxime 9.6
Tacrine 9.6
Pralidoxime chloride 9.6
C23H22O6 9.5
2,3-dihydro-1H-cyclopenta[b]quinoline 9.5
C4H6N2O2 9.5
more...