Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
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Human Gene/Protein
Rho GTPase-activating protein 4 11.3
acetylcholinesterase isoform E4-E6 precursor 11.3
butyrylcholinesterase 11.3
pseudocholinesterase 11.1
CHE1 10.6
Cholinesterase 10.4
RIC8 10.3
RING finger protein 121 10.3
major facilitator superfamily domain containing 1 10.3
leiomodin 2 10.3
RIC-3 9.3
macoilin 9.3
TEPP 9.0
Carboxylesterase 9.0
AChE 8.9
CHED 8.8
ENaCbeta 8.7
COLQ 8.7
acetylcholinesterase 8.7
ACHE 8.5
ABHD10 8.5
lipocalin-1 interacting membrane receptor 8.5
RAB11B 8.5
PLEKHB1 8.5
phosphodiesterase 9A 8.5
neuropathy target esterase 8.5
carboxylesterase 8.3
CTL3 8.3
cholinesterase-related cell division controller 8.3
APBB1 8.2
APH1A 8.1
ADAS 8.1
lamellipodin 8.0
choline acetylase 8.0
dipeptidyl peptidase 9 8.0
ALG14 8.0
arylformamidase 7.8
phosphorylase, glycogen 7.8
NCAD 7.8
OTOG 7.8
more...
Disease
Butyrylcholinesterase deficiency 11.3
Impairment of attention 11.3
Specific disorders of sleep 11.3
Pseudocholinesterase deficiency 10.9
Prolonged neuromuscular block 10.7
Cholinergic crisis 10.6
Thyrotoxic myopathy 10.3
Acute cholestatic hepatitis 10.3
BD syndrome 9.7
urination disorder 9.3
Intercurrent disease 9.0
CHED 8.7
Bronchopulmonary infection 8.7
Subcortical vascular dementia 8.7
Alzheimer's disease with early onset 8.5
Sundowning 8.5
Distal spinal muscular atrophy 8.5
GSM1 8.3
FIF 8.3
Macronodular cirrhosis 8.0
Upbeat nystagmus 8.0
Pisa syndrome 7.9
BPSD 7.9
Dementia in Parkinson's disease 7.8
Congenital Myasthenic Syndromes 7.8
Acute glaucoma 7.6
FRA16A 7.5
Neuronal intestinal dysplasia 7.5
CLAM 7.5
Gulf War Syndrome 7.1
Sleep attacks 7.0
Enzyme inhibition 7.0
Neuromuscular blockade 6.9
MNGIE 6.6
Vascular dementia 6.6
disturbed memory 6.6
Type V hyperlipoproteinemia 6.6
bronchorrhea 6.6
Xanthinuria 6.5
Dementia with Lewy bodies 6.4
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Symptom
Slight fever 11.3
Moist rales 10.3
Antecollis 8.5
ACHE 8.0
Local swelling 7.6
visual hallucination 6.6
redness of the eyes 6.5
Behavioral symptoms 6.5
urological problem 6.4
fasciculation 5.5
frequent urination 5.5
memory loss 5.1
Positive and Negative Symptoms 4.7
apathy 4.3
abdominal cramps 4.2
loss of equilibrium 4.2
leg cramps 4.1
hypalgesia 3.8
Decreased activity 3.8
muscle cramps 3.8
prostration 3.8
blurred vision 3.7
hypoproteinemia 3.7
agitation 3.7
Extrapyramidal symptoms 3.7
giddiness 3.6
giddiness 3.6
Involuntary Movement 3.6
tonic seizure 3.6
twitching 3.5
Multimorbidity 3.4
skin irritation 3.4
aphonia 3.3
rundown 3.3
chest tightness 3.3
lightheadedness 3.3
hyperesthesia 3.2
body pain 3.2
consciousness disturbance 3.2
dark urine 3.2
more...
Drug
Butyrylthiocholine 11.3
Protopam Chloride 11.3
Doxacurium chloride 10.7
Distigmine bromide 10.5
Phospholine Iodide 10.0
Exelon 9.8
Exelon 9.7
Pralidoxime 9.6
Pyridostigmine bromide 9.6
Mestinon 9.5
Mivacron 9.4
Donepezil 9.4
Reminyl 9.3
Aricept 9.3
Echothiophate iodide 9.3
Galanthamine 9.1
Cognex 9.0
Mivacron 9.0
Vanoxerine 9.0
Pyridostigmine bromide 8.8
Edrophonium chloride 8.7
Galantamine hydrobromide 8.6
Cyclogyl 8.5
Sugammadex sodium 8.5
Azilect 8.3
Physostigmine salicylate 8.2
Namenda 8.2
Cyclogyl 8.1
Eserine sulfate 8.1
Malotilate 8.1
Parbendazole 8.0
Prostigmin 8.0
DFP 7.9
Landiolol hydrochloride 7.8
Methscopolamine 7.8
Atracurium besylate 7.6
Gluthathione 7.6
CXN 7.6
2,4,6-Tribromophenol 7.5
THA 7.3
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Enzyme
cholinesterase 11.3
acetylcholinesterase 9.9
aspirin esterase 9.9
AAA-1 8.5
atropine esterase 8.1
DFPase 8.1
carboxylesterase 7.8
carboxypeptidase 1 7.7
paraoxonase 7.7
choline oxidase 7.6
EC 3.1.1.47 7.6
paraoxonase 7.2
EC 1.1.1.38 6.8
acetylesterase 6.7
neuropathy target esterase 6.7
choline acetyltransferase 6.3
esterase D 5.9
kynurenine formamidase 5.9
prolyl endopeptidase 5.7
beta-secretase 5.7
monoacylglycerol lipase 5.6
leucine aminopeptidase 5.6
trimetaphosphatase 5.5
serum carnosinase 5.5
histidase 5.4
cholesterol esterase 5.4
monoamine oxidase 5.3
sorbitol dehydrogenase 5.2
succinic dehydrogenase 5.2
PAM 5.1
gamma-glutamyl transpeptidase 5.0
tyrosinase 5.0
octopine dehydrogenase 5.0
guanase 5.0
choline dehydrogenase 5.0
adamalysin 5.0
NADPH:quinone oxidoreductase 5.0
alanine aminopeptidase 4.9
bleomycin hydrolase 4.9
arylsulfate sulfotransferase 4.9
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Compound
C13H18N2O2 11.3
C13H18N2O2 11.3
F 2268 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
Butyrylcholine iodide 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C28H34N2O6 11.3
C28H34N2O6 11.3
Isoterchebin 11.3
C13H18N2O2 11.3
C28H34N2O6 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
1-Dimethylaminonaphthalene 11.3
Isoxathion 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
Bis(trichloromethyl) sulfone 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
C13H18N2O2 11.3
Belladine 11.3
C13H18N2O2 11.3
Fyrol 6 11.3
C13H18N2O2 11.3
OMPA 10.7
2-butenediamide 10.7
5,6-dichloronicotinic acid 10.7
ethyl methylcarbamate 10.4
Echothiophate 10.4
Mivacurium 10.4
2-phenylacetohydrazide 10.3
2,2-dimethylaziridine 10.3
1,22-docosanediol 10.3
more...