Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
acetylcholinesterase 3650
butyrylcholinesterase 3588
Sep 871
AChE 628
pseudocholinesterase 495
esterase 393
Cholinesterase 389
albumin 327
Mol 324
alkaline phosphatase 279
carboxylesterase 225
catalase 213
amyloid precursor protein 201
choline acetyltransferase 185
lactate dehydrogenase 180
muscarinic receptor 180
NMR 179
aspartate aminotransferase 160
superoxide dismutase 158
alanine aminotransferase 151
serum albumin 150
amylase 137
hemoglobin 124
glucosidase 118
tyrosinase 118
GSH 118
paraoxonase 111
insulin 91
ATPase 91
glutathione S-transferase 89
acetylcholine receptor 88
CA1 87
prothrombin 87
acid phosphatase 82
axonal 82
nicotinic acetylcholine receptor 79
microsomal 76
NMDA receptor 71
BACE1 68
cytochrome P450 66
arylesterase 65
glutathione peroxidase 64
creatine kinase 62
peroxidase 60
lipase 58
MAO-B 55
collagen 55
amyloid beta 54
TNF 53
GABA 52
membrane-bound 52
transferrin 51
endoplasmic reticulum 51
FRAP 51
Gen 50
carbonic anhydrase 47
lipoxygenase 46
ESI 45
ADAS 44
5-hydroxytryptamine 44
AST 43
ATP 43
serum protein 43
caspase-3 43
gut 43
Carboxylesterase 42
apolipoprotein E 42
GPT 41
LDH 41
MAO-A 41
SDS 40
neuropathy target esterase 40
gamma-glutamyltransferase 38
Pol 38
substance P 37
thymus 37
She 36
cytokine 36
MRI 35
glycoprotein 35
hole 35
HDL 33
olfactory 33
lipopolysaccharide 33
prealbumin 33
nerve growth factor 33
CAS 32
BACE 32
glutamate dehydrogenase 32
SOD 32
muscarinic acetylcholine receptor 31
adenosine deaminase 31
somatostatin 31
APP 30
ACS 30
PON1 30
growth hormone 30
IL-6 30
TOF 30
alpha-fetoprotein 29
glutathione reductase 29
CSF 29
tumor necrosis factor 29
cytochrome P-450 28
APOE 28
polypeptide 28
leucine aminopeptidase 28
tau protein 28
brain-derived neurotrophic factor 28
C-reactive protein 28
glial fibrillary acidic protein 27
proline-rich 27
xenobiotic 27
Pseudomonas 27
cytochrome 27
adenosine triphosphatase 27
GABA(A) receptor 26
peptidase 26
glucose-6-phosphate dehydrogenase 26
kit 26
gamma-glutamyl transpeptidase 25
PAM 25
alpha-amylase 25
fibrinogen 25
dimeric 25
AMP 25
haptoglobin 24
Choline acetyltransferase 23
GST 23
fused 23
myeloperoxidase 23
Bcl-2 22
ACHE 22
CAT 22
chymotrypsin 22
lectin 21
AChR 21
serine hydrolase 21
ROS 21
ghrelin 21
interleukin-6 21
SAR 21
nitric oxide synthase 20
collagenase 20
vesicular acetylcholine transporter 20
ANOVA 20
calcium channel 20
GHRH 19
antioxidant enzyme 19
thyroglobulin 19
brain) 19
tyrosine hydroxylase 19
CA3 19
inducible nitric oxide synthase 19
P450 18
ceruloplasmin 18
choline transporter 18
SCH 18
glutamate receptor 18
CYP2D6 18
more...
Disease
Alzheimer's disease 2286
dementia 792
depression 329
cognitive impairment 313
Parkinson's disease 191
cirrhosis 178
myasthenia gravis 162
cancer 141
diabetes 139
GSH 118
fits 108
memory impairment 105
neuroblastoma 90
psychosis 90
tumor 88
hallucinations 87
liver disease 72
amnesia 67
plaque 66
hypertension 65
obesity 59
hepatocellular carcinoma 57
Dementia with Lewy bodies 57
neuropathy 49
parkinsonism 48
malnutrition 47
stroke 47
Evans 46
respiratory failure 43
chronic hepatitis 41
schizophrenia 41
SDS 40
myasthenia 39
delusions 39
ischemia 38
cold 38
epilepsy 36
SEM 36
delirium 35
hepatitis 34
anemia 34
glaucoma 33
hyperglycemia 33
type 2 diabetes 32
cognitive deficit 32
suicide 32
coma 31
carcinoma 30
fatty liver 30
Huntington's disease 29
senile dementia 29
cocaine abuse 27
cardiovascular disease 26
autoimmune disease 26
PAM 25
varices 25
Down syndrome 24
chronic liver disease 24
worms 23
addiction 23
hyperlipidemia 23
malaria 22
HIV 22
cholestasis 22
leukemia 22
multiple sclerosis 22
asthma 21
aggression 21
SAR 21
sepsis 20
heart failure 20
sepsis 20
prolapse 20
hepatitis B 19
West 19
thymoma 18
atherosclerosis 18
SCH 18
cocaine addiction 18
acute hepatitis 17
hypothyroidism 17
pheochromocytoma 17
schistosomiasis 16
encephalopathy 16
chronic active hepatitis 16
muscular dystrophy 16
uterus 16
breast cancer 15
confusion 15
Vascular dementia 15
liver cancer 15
myopathy 15
hypercholesterolemia 15
pneumonia 15
major depressive disorder 15
diplopia 14
hepatitis C 14
status epilepticus 14
MCF 14
thrombocytopenia 14
metabolic syndrome 14
sleep disorders 14
sleep disturbances 14
disinhibition 14
tumorigenesis 13
hyperthyroidism 13
Enzyme inhibition 13
myocardial infarction 13
polyneuropathy 13
esophageal varices 13
vascular disease 13
lung cancer 13
pruritus 13
myocardial ischemia 13
abortion 12
tetanus 12
portal hypertension 12
viral hepatitis 12
Neuromuscular blockade 12
tuberculosis 12
mental illness 12
autism 12
proteinuria 12
amyotrophic lateral sclerosis 12
coronary artery disease 11
psychological stress 11
liver cancer 11
liver fibrosis 11
hyperhomocysteinemia 11
intraocular pressure 11
infectious diseases 11
peripheral neuropathy 11
neurological disease 11
alcoholic cirrhosis 11
alcoholism 11
Dermal 11
hyperlipoproteinemia 11
pulmonary edema 11
Syndrome 11
brain atrophy 11
progressive supranuclear palsy 11
dysphagia 11
PCP 10
cornea 10
incontinence 10
Best 10
TEM 10
renal failure 10
renal disease 10
papillary thyroid cancer 10
pancreatitis 10
suicide attempts 10
disseminated intravascular coagulation 9
carcinogenesis 9
LAP 9
CNS diseases 9
chronic renal failure 9
TEM 9
cerebral ischemia 9
chronic obstructive pulmonary disease 9
more...
Symptom
anesthesia 215
weakness 133
seizures 132
pain 66
diarrhea 65
agitation 62
vomiting 58
tremor 54
nausea 52
memory loss 50
headache 47
fatigue 45
hypothermia 41
ataxia 37
apathy 32
dizziness 30
analgesia 26
ACHE 24
fasciculation 23
respiratory distress 23
dyspnea 20
anorexia 20
exhaustion 18
sleepiness 17
nausea and vomiting 15
overweight 14
abdominal pain 14
cough 13
syncope 13
functional recovery 13
collapse 12
blurred vision 11
insomnia 11
visual hallucination 11
constipation 10
acute stress 10
lethargy 9
twitching 9
skin irritation 9
splenomegaly 8
myalgia 8
rhinorrhea 8
paresis 8
dystonia 8
flushing 7
erythema 7
hepatomegaly 7
discomfort 7
spasm 6
incoordination 6
spasticity 6
thinning 6
hypoproteinemia 6
paresthesia 6
ophthalmoplegia 6
bradykinesia 6
Ill 6
vertigo 5
muscle cramps 5
asthenia 5
starvation 5
hypercapnia 5
discomfort 5
abdominal cramps 4
chest pain 4
hypotonia 4
epigastric pain 4
acidity 4
stigma 3
frequent urination 3
chills 3
Behavioral symptoms 3
consciousness disturbance 3
chest tightness 3
emaciation 3
Decreased activity 3
cyanosis 3
ENT 3
despair 3
arthralgia 3
tachypnea 3
sore throat 3
muscle rigidity 3
rales 2
Hudson 2
prostration 2
cachexia 2
hunger 2
Sedation 2
heartburn 2
lightheadedness 2
chronic constipation 2
Gastrointestinal symptoms 2
shortness of breath 2
Depressive symptoms 2
nasal discharge 2
eds 2
Postoperative pain 2
angina 2
pallor 2
hyperesthesia 2
numbness 2
dysarthria 2
torticollis 2
dysuria 2
tonic-clonic seizure 2
abdominal discomfort 2
excessive sweating 2
Involuntary Movement 2
dry skin 2
rundown 2
leg pain 2
myoclonus 2
regurgitation 2
hyperoxia 1
Positive and Negative Symptoms 1
back pain 1
tingling 1
blepharospasm 1
hemoptysis 1
Extrapyramidal symptoms 1
distraction 1
wheezing 1
skin damage 1
hepatosplenomegaly 1
hypocapnia 1
personality change 1
partial seizure 1
cerebellar ataxia 1
Multimorbidity 1
polydipsia 1
dark urine 1
forgetfulness 1
nasal congestion 1
eye pain 1
Burning 1
hypalgesia 1
loss of taste 1
limb pain 1
Welt 1
chorea 1
giddiness 1
giddiness 1
body pain 1
stridor 1
Local swelling 1
urological problem 1
aphonia 1
motor symptom 1
tinnitus 1
dental pain 1
redness of the eyes 1
sinus pressure 1
hopelessness 1
ketonuria 1
otalgia 1
muscle stiffness 1
polyuria 1
Moist rales 1
Fluctuation 1
more...
Drug
Donepezil 149
Atropine 100
DFP 90
vitamin E 61
THA 58
Scopolamine 37
CSF 32
lysine 28
Aricept 27
Monit 24
Pyridostigmine bromide 23
ascorbate 22
ROS 21
EDR 20
Albumin 17
Pyridostigmine bromide 16
Pralidoxime 16
EPA 16
caffeine 15
Nephron 15
NADH 15
Exelon 14
Galanthamine 14
Vitamin E 14
Dermatol 13
CTX 13
Serum albumin 12
Gel 12
Exelon 12
Leaf 12
Glutathione 10
Distigmine bromide 10
Cardiovasc 9
citric acid 9
Clonidine 9
Mestinon 9
PCP 8
TAK 8
Ethanol 8
CPT-11 8
Pilocarpine 8
Reminyl 8
lactose 7
Spectrum 7
Rocuronium 7
ROC 7
Mutagen 7
Ringer's solution 6
EE2 6
Fraction 6
Diphenhydramine 5
ENT 5
ALA 5
Azilect 5
p75 5
Cognex 5
Brij 96 4
Namenda 4
9-THC 4
Ginseng 4
HCH 4
Reserpine 4
PTC 4
Forskolin 4
Prednisone 4
niacin 4
ampicillin 4
Ranitidine 4
CaCl2 4
CaCl2 4
CaCl2 4
DMAA 4
MRC 4
Piracetam 4
Histamine 4
BTC 4
Tubocurarine 3
Fluorescein 3
Limonene 3
ZnO 3
CPO 3
Asn 3
Phenytoin 3
TAC 3
Rutin 3
Methylene blue 3
ACT 3
Azithromycin 3
Pronase 3
Mivacron 3
Portal 3
Ouabain 3
Senna 3
Dial 3
Glycyrrhiza 3
Prostigmin 3
Bupivacaine 3
Ciclesonide 3
Senna 3
Galantamine hydrobromide 3
Malotilate 3
Prednisolone 3
Rasagiline 3
TTC 3
Capsicum 3
Thyroglobulin 3
Colistin 2
CoCl2 2
Butyrylthiocholine 2
Propanidid 2
Cisapride 2
Ceruletide 2
CoCl2 2
Ketoconazole 2
Compound 9 2
Glycerol 2
Adenosine deaminase 2
Epigallocatechin 2
Compound 16 2
IL-2 2
ICI 2
Cimetidine 2
Vitamin K 2
CTX 2
Domperidone 2
Human Serum Albumin 2
Vitamin B12 2
CTX 2
Idebenone 2
Doxacurium chloride 2
VCR 2
Atracurium besylate 2
Gallamine 2
Timolol 2
Propentofylline 2
Frontal 2
VCR 2
IFN-gamma 2
Edrophonium chloride 2
Modafinil 2
Cimetidine 2
Nephron 2
PCB 2
TiO2 2
nitroglycerin 2
Phentolamine 2
Magnesium sulfate 2
Loxiglumide 2
Antithrombin III 2
Physostigmine salicylate 2
Phospholine Iodide 2
Arfonad 2
Asthma 2
MAP 2
Spectrum 2
Rokitamycin 2
Arsenic trioxide 2
Galactose 2
RBT 1
MIL 1
more...
Enzyme
cholinesterase 12691
acetylcholinesterase 11108
alkaline phosphatase 281
carboxylesterase 267
alanine aminotransferase 250
catalase 222
aspartate aminotransferase 205
lactate dehydrogenase 201
choline acetyltransferase 192
superoxide dismutase 184
monoamine oxidase 163
paraoxonase 142
paraoxonase 126
gamma-glutamyl transpeptidase 119
tyrosinase 118
ATPase 116
glutathione S-transferase 111
peroxidase 92
acid phosphatase 83
creatine kinase 80
glutathione peroxidase 65
lipase 65
trypsin 59
carbonic anhydrase 50
lipoxygenase 46
neuropathy target esterase 43
AST 42
succinate dehydrogenase 41
glutamate dehydrogenase 34
glutamate dehydrogenase 34
glutamate dehydrogenase 34
choline oxidase 33
chymotrypsin 33
deaminase 33
leucine aminopeptidase 31
adenosine deaminase 31
adenosine deaminase 31
ACS 30
caspase-3 30
glucose-6-phosphate dehydrogenase 30
glutathione reductase 29
urease 28
urease 28
protein kinase 27
protein kinase C 27
mitogen-activated protein kinase 27
pepsin 27
aldolase 26
succinic dehydrogenase 25
ERK 25
alpha-amylase 25
PAM 25
malate dehydrogenase 23
cytochrome oxidase 21
collagenase 20
ceruloplasmin 19
beta-secretase 19
diaphorase 19
ACE 19
tyrosine hydroxylase 18
prolyl endopeptidase 17
phosphorylase 17
CYP3A4 17
phosphodiesterase 17
beta-glucuronidase 16
cholesterol esterase 16
sorbitol dehydrogenase 16
phospholipase C 15
GSK 15
demethylase 14
glucose-6-phosphatase 14
thrombin 14
isocitrate dehydrogenase 13
NADPH-diaphorase 13
5'-nucleotidase 13
monoacylglycerol lipase 13
arginase 12
aspirin esterase 12
NQO1 12
diaphorase 10
hexokinase 10
focal adhesion kinase 10
aldose reductase 10
phospholipase A2 10
lipoprotein lipase 10
phosphoglucomutase 10
UDP-glucuronosyltransferase 9
alanine aminopeptidase 9
neuraminidase 9
alpha-glucosidase 9
acetylesterase 9
alcohol dehydrogenase 9
pyruvate kinase 9
isocitrate dehydrogenase 9
thromboplastin 9
CPR 9
PCP 8
cathepsin D 8
nucleotidase 8
delta-aminolevulinic acid dehydratase 8
beta-galactosidase 7
CD10 7
lecithin:cholesterol acyltransferase 7
lysozyme 7
elastase 7
tyrosine aminotransferase 7
aldehyde dehydrogenase 7
papain 7
xanthine oxidase 7
GCA 7
DFPase 7
hyaluronidase 6
PDE 6
esterase D 6
prolidase 6
enolase 6
glycerol-3-phosphate dehydrogenase 6
6-phosphogluconate dehydrogenase 6
6-phosphogluconate dehydrogenase 6
hyaluronidase 6
reverse transcriptase 6
glycerol-3-phosphate dehydrogenase 6
dipeptidyl peptidase IV 6
renin 6
CD13 5
PGM 5
transpeptidase 5
adenylate kinase 5
sulfatase 5
cholesterol acyltransferase 5
Mg2+-ATPase 5
MDH 5
NOS 5
carnitine acetyltransferase 5
NO synthase 5
MDH 5
PARP 5
ADH 5
APC 5
N-acetyltransferase 4
MIP 4
luciferase 4
phosphoenolpyruvate carboxykinase 4
AAA-1 4
sialidase 4
caspase-9 4
AMPK 4
diamine oxidase 4
phosphoenolpyruvate carboxykinase 4
histidase 4
RNase 4
tissue plasminogen activator 4
phosphoenolpyruvate carboxykinase 4
RNase 4
urokinase-type plasminogen activator 4
P-glycoprotein 3
guanylate cyclase 3
lactonase 3
beta-glucosidase 3
transglutaminase 3
more...
Compound
Dec 848
water 637
Clin 588
phosphate 264
glucose 258
sodium 246
calcium 244
DNA 244
ACh 226
oxygen 213
serine 169
urea 161
hydrogen 156
galanthamine 153
bromide 147
DPPH 147
acetate 146
nitrogen 145
glutamate 144
creatinine 139
methanol 134
iodine 129
GSH 128
GSH 128
PAM 124
potassium 123
OMPA 121
Physostigmine 119
sulfate 112
ethanol 110
ethyl acetate 109
Rivastigmine 101
Atropine 100
Tacrine 98
nitric oxide 98
salt 91
silver 90
ammonium 87
iron 86
Chlorpyrifos 84
His 84
phosphorus 83
DDVP 82
noradrenaline 80
pyridine 78
copper 74
zinc 74
tyrosine 73
galactose 69
alanine 63
5-HT 62
hexane 62
arginine 61
NMDA 60
Triton X-100 57
phenol 56
Gly 55
GABA 55
TNF 53
piperidine 53
piperidine 53
GABA 52
chloroform 52
DEP 51
Soman 48
Neostigmine 48
Pyridostigmine 47
Succinylcholine 43
Mivacurium 43
ATP 43
cadmium 42
Diazinon 42
SDS 42
leucine 41
GPT 41
Memantine 41
mercury 40
4-nitrophenyl 39
Asp 38
palmitic acid 37
tryptophan 37
dichloromethane 37
quinoline 36
acetic acid 36
Pac 36
benzene 36
quinoline 36
tryptophan 35
tryptophan 35
cysteine 35
tryptophan 35
Choline 35
Paraoxon 35
SEE 34
lysine 34
Sarin 33
EDTA 33
TMB-4 33
gallic acid 32
EDTA 32
fluorine 31
Mg2+ 30
ACS 30
ACS 30
QNB 30
DAD 30
TOF 30
PAM 29
O,O-diethyl 29
ammonia 29
gamma-aminobutyric acid 29
nitrate 29
PAM 29
Panam 29
glutamine 28
Cocaine 28
2-pyridinol 28
2-pyridinol 28
MDA 28
MTT 28
2-pyridinol 28
H2O2 27
PAS 27
AMP 27
methionine 27
methyl carbamate 26
Phe 25
acetone 25
PEG 25
proline 25
threonine 24
Carbofuran 24
acrylamide 24
ASA 23
Formal 23
manganese 23
cAMP 23
glycerol 23
isoquinoline 22
Nicotine 22
kaempferol 22
MEP 22
CAT 22
CAT 22
aspartic acid 22
selenium 22
CAT 22
acridine 22
benzoic acid 21
cobalt 21
DDT 21
NH2 21
Tris 21
HCl 20
aluminum 20
piperazine 20
aldehyde 19
acetonitrile 19
6-12 19
chalcone 19
more...