Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.8 (
cholinesterase
)
12,691
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The grayanotoxin III (
GTX
III) was given intraperitoneally to rats at a dose of 0.8 or 2.8 mg/kg. To study the effects of
GTX
III on rats, biological tests in serum for functions of liver and kidney and their pathological observation were performed 1 h after the administration. Using analysis of variance, multiple comparison and correlation on biological parameters, activities of glutamic-pyruvic transaminase (GPT), guanase and leucine aminopeptidase and concentrations of total protein, albumin, creatinine, uric acid and K increased significantly. These parameters showed dose-effect relations with
GTX
III. Though GPT and free fatty acid increased significantly, dose-effect relations were not shown. The activity of
choline esterase
and the concentrations of bilirubin, urea-N, lipoperoxide, cholesterol, triglycerides, Na and Cl were not significantly different. Pathological changes were not observed in the liver and kidney of rats. These results show that
GTX
III may affect the functions of liver and kidney in rats.
...
PMID:[Effects of grayanotoxin III on liver function and renal function in rats]. 262 64
