Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rifabutin exhibits remarkable autoinduction of its elimination, but the mechanism behind it was not fully known. Our work showed that rifabutin administration increased the metabolism of rifabutin itself in both in vivo studies and liver perfusion, and the half-life was decreased by 71.08% and 12.74%, respectively. Further results showed that rifabutin administration increased CYP3A, CYP2D and cholinesterase levels by 87.2%, 57.3% and 65.14%, respectively. The autoinduction phenomenon of rifabutin may, therefore, be attributed to induction of cholinesterase and CYP450 isoenzymes, such as
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PMID:Rifabutin autoinduction is caused by involvement of cytochrome P450 and cholinesterase. 1838 Apr 4