Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.8 (
cholinesterase
)
12,691
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Coated vesicles isolated from rat liver perfused with diisopropylfluorophosphate (DFP) to inactivate endogenous
cholinesterase
contained newly synthesized secretory
cholinesterase
after a 30 min recovery. The
cholinesterase
is found in coated vesicles of presumed endocytic origin following DFP treatment and perfusion for 3 min with galactosylated
cholinesterase
, a ligand for the
asialoglycoprotein receptor
. Highly enriched populations of endocytic and exocytic coated vesicles can be separated by use of a novel
cholinesterase
mediated density shift technique. The two coated vesicle classes have very similar polypeptide compositions but differ significantly in the ratio of cholesterol to phospholipid.
...
PMID:Separation of endocytic from exocytic coated vesicles using a novel cholinesterase mediated density shift technique. 286 30
Butyrylcholinesterase administration has been shown to block the effects of cocaine. However, even in model systems, the pharmacokinetics of the enzyme are only partly understood. Measurements of plasma enzyme concentration, antibody titer determinations, and measurement of cocaine-induced locomotor activity in mice were used to describe the disposition of
butyrylcholinesterase
. Clearance of the enzyme showed biexponential kinetics; the first component was sensitive to asialofetuin, suggesting a role for the
asialoglycoprotein receptor
. Cocaine did not influence enzyme disposition. An antibody response to enzyme injection was seen; the role of this response is not clear. The antagonist effect of the enzyme was eliminated faster than the enzyme was eliminated from plasma; this may be due to a contribution of tissue esterases to cocaine metabolism. Intraperitoneal enzyme administration was not effective against cocaine, suggesting that the utility of the enzyme is route-dependent.
...
PMID:Characterization of equine butyrylcholinesterase disposition in the mouse. 1201 1
