Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.8 (
cholinesterase
)
12,691
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
4-Methyl-2-aminopyridine
(
4M2AP
) increased responses of isolated rat diaphragm and chick biventer cervicis nerve-muscle preparations to nerve stimulation but depressed responses to direct stimulation. Responses to acetylcholine were also increased while responses to carbachol were depressed. When tested after inhibition of acetylcholinesterase activity with neostigmine the effect of
4M2AP
on responses to indirect stimulation was greatly reduced and responses to acetylcholine were depressed. It is concluded that, in contrast to other aminopyridines,
4M2AP
facilitates neuromuscular transmission by inhibition of
cholinesterase
rather than augmenting release of acetylcholine and depresses rather than enhances muscles contractility.
...
PMID:Actions of 4-methyl-2-aminopyridine on neuromuscular transmission and contractility of skeletal muscle. 626 May 15
