Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rats were treated, during 8 weeks, with different doses of edifenphos (0, 5, 10, 20, 40 mg/kg/day) incorporated in the food. Treatments with 20 and 40 mg/kg increased the relative liver weight and hepatic concentrations of phospholipids, microsomal proteins and cytochrome P450. Aminopyrine N-demethylase and aniline hydroxylase activities were increased at the same doses. Hepatic lipids and blood triacylglycerols remained unchanged by the treatment, but blood cholesterol increased significantly (33%) at 40 mg/kg. Plasma cholinesterase activity was slightly depressed in rats treated with the two higher doses. Under these experimental conditions, the dose of edifenphos, inducing no significant difference was 10 mg/kg/day.
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PMID:Biochemical changes in liver and plasma of rats after oral administration of edifenphos. 683 11

The effects of fenitrothion and methylparathion on the activities of cholinesterase and hepatic microsomal monooxygenases were investigated and compared following a single or repeated oral administration of an equimolar and low dose of the insecticides. The activities of cholinesterase in brain and plasma were inhibited equally by the repetitive administration of both insecticides. Aminopyrine N-demethylase activity and cyt.P-450 content were not affected under the same experimental conditions. However, methylparathion, when given repeatedly, inhibited the dearylation and desulfuration of it own. The results may indicate that low dose continuous exposure to methylparathion could cause the depression of its own metabolism in rat.
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PMID:Comparison of the effect of an equimolar and low dose of fenitrothion and methylparathion on their own metabolism in rat liver. 709 8

Aminopyrine breath test was investigated in 268 patients with various liver disease. From the specific activity for six hours after ingestion of a tracer dose the elimination rate in percent per hour is calculated. Comparing to 47 controls the elimination rate is reduced about 20% in patients with chronic persistent hepatitis (49 patients) and fatty liver (84 patients). In 42 patients with chronic active hepatitis the elimination rate is reduced to 48% and in 54 patients with cirrhosis to 64%. Between aminopyrine breath test and indocyaningreen test or cholinesterase and albumin no correlations were found. Aminopyrine breath test is a sensitive, non-invasive test and specific in liver function and therefore useful in the follow up of patients with known liver disease.
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PMID:[The diagnostic relevance of the aminopyrine breath test in liver disease]. 718 67