Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.8 (
cholinesterase
)
12,691
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The content and hydrophobic properties (distribution coefficient in hexan : water) of organophosphorus inhibitors
OPT
of the following structure--R-O (CH3)/P/O/S C2H4SC2H5 have been studied in rat brain. On enlargement of the O-alkyl radical from ethyl to isopropyl and pinacolin hydrophobecity increases from 1 to 12 and 39, while the relative content of the chloroform extractable free
OPT
in brain, under conditions of uniform distribution, decreases from 11--18% to 3.2%. On incubation of the homogenate at 37 degrees C the further inhibition of the specific
cholinesterase
of the brain indicates the presence of an absolutely free form of
OPT
, the amount of which is not dependent on the degree of its hydrophobicity.
...
PMID:[Forms of deposition of phosphoorganic cholinesterase inhibitors in the brain]. 123 72
