Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

After intraperitoneal administration of acrylonitrile into rats, fructose monophosphate aldolase was found in blood serum, activity of butyryl cholinesterase was inhibited but activity of alkaline phosphatase was unaltered in rat blood serum; these data demonstrate the necro-bystrophic type impairment. Decrease in the hepatotoxic effect of acrylonitrile after preadministration of antioxidants appears to be a result of stimulation of lipid peroxidation, preventing the toxic effect of this industrially important substance.
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PMID:[Blood serum enzymes in assessing the nature of the liver lesion and the effectiveness of chemotherapeutic actions in acrylonitrile poisoning]. 51 33

The inevitable chemical risks present in a synthetic threads and fibres aggregate works determine a careful and permanent surveillance of employees' state of health, especially where the occupational risk is known to exist. Besides the usual labour protection measures, screening for the early detection of some biochemical or biotoxicological changes induced by the contact with the chemical noxae in the labour environment are performed. This paper presents the results of a complex biochemical and biotoxicological screening including about 300 employees working at the polyplants in the melanin section where the major chemical noxa is acrylonitrile. The total proteins, hemoglobin, methemoglobin and cholinesterase activity were determined.
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PMID:[Biotoxicological research on a segment of the population in an industrial environment. I. Total proteins, hemoglobin, methemoglobin and cholinesterase]. 210 Aug 52

The effects of acute exposure to acrylonitrile (ACN), 10, 20, or 40 mg/kg by gavage, on the ability of metrazol (MTZ) to induce seizures was studied in adult, male Sprague-Dawley rats. The frequency of seizure occurrence and the frequency of a lethal seizure was greater when the high ACN dosage was given in combination with metrazol. This dosage of ACN was not lethal when given alone. Examination of brain tissue in these animals revealed no difference in cyanide levels when MTZ was combined with ACN. However, brain cytochrome c was significantly lower in animals given ACN+MTZ and brain cholinesterase was significantly higher. These results suggest that the enhanced lethality occurring in animals exposed to the combination of ACN+MTZ is not due to cyanide, a metabolic product of ACN, but rather to a potentiation of other effects of ACN perhaps involving cholinergic neurotransmission.
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PMID:Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat. 298 62