Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of quinalphos on blood esterases was investigated in male buffalo calves after daily oral doses of 0.7, 1.4 and 2.1 mg/kg body weight for 28 consecutive days. Quinalphos markedly inactivated serum carboxylesterase (69-90%) and plasma cholinesterase activity (75-88%). Esterase activities in animals receiving 0.7 mg/kg/day of quinalphos approached normal levels 14 days after the termination of its ingestion. The results suggest that quinalphos is an effective inhibitor of blood esterases in vivo and its repeated exposure to buffaloes may impair detoxification of organophosphorus insecticides that are mainly biodegraded by carboxylesterase enzyme.
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PMID:Effect of repeated oral administration of quinalphos on blood esterases in Bubalus bubalis. 665 22

Incidence of numerous human poisonings by quinalphos (Ekalux, Bayrusil) in agricultural areas near Belgrade initiated this study on the ability of the compound to inhibit hen brain neuropathy target esterase, acetylcholinesterase and plasma butyrylcholinesterase in vivo. Hens were treated with a single oral dose ranging from 25 to 600 mg kg-1 quinalphos (LD50 = 72 mg kg-1) or 500 mg kg-1 triorthocresyl phosphate (positive control), sacrificed 24-96 h later for enzyme assays and monitored for 25 days for evaluation of walking impairments. High inhibition (> 80%) of both cholinesterases was obtained with 25 and 50 mg kg-1 quinalphos. Doses of 200 and 600 mg kg-1 of the agent inhibited up to 23 and 28% of hen brain neuropathy target esterase activity, respectively. Clinical signs of neuropathy were not seen. Quinalphos was slowly absorbed from the gastrointestinal tract, as indicated by the severity of the cholinergic symptoms and the inhibition of neuropathy target esterase, which reached its maximum 72 and 96 h after poisoning. The results suggest that quinalphos, at doses tested, has no ability to cause delayed neuropathy in hens without showing signs of severe cholinergic intoxication.
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PMID:Studies on the delayed neuropathic and anticholinesterase potential of quinalphos (diethyl 2-quinoxalyl phosphorothionate) in hens. 825 30