Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The synthesis of styrylpyridine methiodides where a hydrogen of the pyridyl moiety was replaced by the hydroxyiminomethyl group produced highly effective inhibitors of acetylcholinesterase. As starting materials 4-methylpyridine-2-aldoxime and 2-methylpyridine-4-aldoxime methiodides were prepared which, together with 4-imidazolylethenyl-pyridine-2-aldoxime methiodide, were the only substances for which some activity as reactivators of phosphorylated electric eel cholinesterase in vitro could also be found.
 ...
PMID:Structure-activity relationships in reactivators of organophosphorus-inhibited acetylcholinesterase. 10. Hydroxyiminomethylarylethenylpyridine methiodides. 117 61