Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the liver of rats fasting for 2,5,8 and 11 days the activity of kathepsins A, B1, C, D, phospholipases A1, A2 and of the cholinesterase was determined. Reciprocal relations in the change of the kathepsins A and D activity was revealed, whereas the kathepsins B1 and C showed a substantial fall. Of the phospholipases A1 and A2 was characteristic a progressive decline of the activity up to the 8th day of fasting. At the terminal stage a brusque activation of phospholipases, largely of the A1 phospholipase was observed, the activity of the latter reaching 205 per cent of the control level. The cholinesterase activity was consecutively declining throughout the whole of the experiment. The data obtained bear evidence to an important role of the kathepsins A and D in the adaptation of the organism to conditions of the endogenous nutrition.
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PMID:[Effect of prolonged fasting on cathepsin and lipolytic enzymatic activities of the rat liver]. 71 29

An investigation was carried out of the metabolic processes, and some procedures for standardizing them, for patients with severe burns receiving uniformly distributed dosified high-calorie catheter alimentation, i.e. enteral hyperalimentation, in addition to the hospital's daily diet. Fifteen types of mixtures of Combustal were used, made and preserved ad hoc, and two commercial probe alimentation liquid products--Biosorbin-MCT (Pfrimmer-Kabi) and Fresubin (Fresenius AG). The average period taken to normalize the nitrogen balance was sixteen days counted from commencement of hyperalimentation. While it shifted the nitrogen balance figures from negative to positive, it was also seen to reduce A and C phospholipase activities in serum, while the level of excretion of nitrogenated amino acids and creatine remained high. During this time, pseudocholinesterase activity dropped, with the concentration of fibronectine in serum, which indicates low levels of biosynthetic processes and insufficiency in the reticuloendothelial system. The average value for the determination of lipids in general remained normal throughout the catheter feeding period. To ensure complete normalization of the metabolic process in patients suffering severe burns, enteral hyperalimentation must be extended for at least one month.
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PMID:[The correction of metabolic disorders in severely burned patients by enteral hyperalimentation]. 147 52