Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Authors have evaluated the serum cholinesterase activity in patients subjected to 2 different schemes of polychemotherapy: COP (CTX, VCR, Prednisone) and C-MOPP (CTX, VCR, PCZ, Prednisone). The two schemes involve the administration of cyclophosphamide that, as has already been proved, significantly lowers serum cholinesterase level after only a few hours. The Authors have observed that the combination of cyclophosphamide with other antiblastic drugs or a longer treatment have little influence on the down curve of the serum cholinesterase in relation to what they have observed after treatment with cyclophosphamide alone.
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PMID:[Evaluation of serum BuChe activity during polychemotherapy based on COP and C-MOPP protocols]. 733 62

As the Authors and Others have already demonstrated, cyclophosphamide leads to a rapid and prolonged decrease in the serum cholinesterase activity. In this work, the behaviour of the serum cholinesterase in patients subjected to C M F polychemotherapy (CTX, VCR, FU) has been studied. The grouping of patients on the basis of serum cholinesterase values before treatment has demonstrated that the enzymatic activity decrease arrives at level practically homogeneous. A month after interruption of therapy values equal to those at starting point have been observed.
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PMID:[Variations of serum BuChe activity during C M F therapy]. 733 63