Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was aimed to examine whether disulfiram (DS) may exacerbate the pre-existing liver damage induced by D-galactosamine (GalN) in rats. DS, 600 mg/kg, administered by gavage for 3 days caused an increase in asparagine aminotransferase (AspAT) and alkaline phosphatase (AP) and a decrease in cholinesterase (ChE) activity in the serum and decrease in AspAT and ChE activity in the liver. DS given to rats with GAlN-induced liver injury caused significant increase in alanine aminotransferase (A1AT) and bilirubin level in serum in comparison with rats with GalN-damaged liver but without DS treatment. In summary, DS exacerbates a damage of the liver of rats. This study supported the clinical observations showing enhanced liver damage in alcoholics treated with DS.
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PMID:Effect of disulfiram on function of the liver of rats with galactosamine-induced hepatitis. 309 1

An injection of 20 micrograms/l kg body wt of adrenaline, acetylcholine and histamine decreased AspAT and A1AT aminotransferase activity in blood plasma serum of 1 to 3-day-old Leghorn chicks. All hormones injected caused an increase in the activity of cholinesterase 1 min after injection.
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PMID:The effect of adrenaline, acetylcholine and histamine on aminotransferase A1AT and AspAT and cholinesterase activity in blood plasma of 1 to 3-day-old chicks. 669 84