Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two natural population of house flies from the Podol'sk District, Moscow Province have been studied. The both natural populations proved to be highly resistant to organophosphorus insecticides and sensitive to pyrethroids. The activity of esterases and glutathione-S-transferase has been studied, as well as the sensitivity of the enzymes of esterase complex in vitro to TBTP, DDVP and paraoxon, as compared with that of the sensitive strain SRS. Reliable differences have been established in the sensitivity of non-specific esterases to organophosphorus compounds. The esterase spectrum of enzymes from heads and abdomens of house flies has been studied by electrophoresis in PAAG and the zones of esterase activity have been revealed in the presence of two substrates: 2-HA and ATX. Differences in the activity of catecholamine esterase and cholinesterase and inn the sensitivity of cholinesterase from the natural populations to organophosphorus compounds have been established.
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PMID:[The enzyme systems in natural populations of the housefly Musca domestica highly resistant to organophosphate insecticides]. 822 81