Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.8 (cholinesterase)
 12,691 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of the work was to specify the possibilities of the use of the enzymes of mediator metabolism: monoamine oxidase (MAO) of platelets, amine oxidase (AO) of serum and acetyl cholinesterase (ACE) of red blood cells to estimate the structure of depressions and to predict their therapeutic dynamics. 32 patients in the depressive phase of MDP were examined. There were 28 women and 4 men aged 22 to 50 years. The monopolar type was recorded in 28 patients, the bipolar one in 4 (all women). The total disease duration amounts to 0.5-17 years; depression may last from 2 months to 4 years. Depending on the type of the dominant affect the patients were distributed into 2 groups (10 persons had melancholic and 22 anxious depression). It has been shown that activity of platelet MAO and serum AO was significantly higher in anxious than in melancholic depression. An interrelationship was established between activity of these enzymes before treatment and prognosis of the treatment with tricyclic antidepressants. Activation of the enzymes during therapy was parallelled by positive clinical changes. Activity of platelet MAO turned out most significant in terms of prognosis. The data obtained are analyzed from the standpoint of regarding depression as a stressful condition, with the participation of the neurohormonal axis: the hypothalamus, pituitary, and adrenal cortex.
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PMID:[Significance of various enzymes of mediator metabolism for evaluation of depression and therapeutic prognosis]. 131 64

A new method to determine ureteral motility by means of radioisotopes is presented. After administration of 99m-Tc-MDP or 99m-Tc-DTPA urine transport within the ureter is documented by functional way-time-matrices. The special resolution results of a series of 7 to 12 regions of interest covering the ureter out of which the information about its motility is extracted from a series of 300 to 480 single pictures. The time resolution is 1 to 2.5 seconds. The observation period varies between 5 and 20 minutes. Urine transport is outlined as an declined stripe in the matrix. Retroperistaltic waves or dyskinesies can also be detected with this method. 31 patients in whom radical surgery was performed for carcinoma of the cervix were examined by the described functional ureter test. The results show that changes in ureteral function like frequency or quality or even retroperistaltic contractions of the ureter can be observed by the urokinetogram, changes which can be traced neither by isotope renogram nor by intervenous pyelography. Similar observations could be made in 10 patients treated by radiotherapy. In 26 patients the influence of sympathico- and parasympathicomimetic agents on the ureteral motility was studied. The results show that an increase of contraction frequency can be obtained by alpha- and betamimetics and also by cholinesterase inhibitors. These results which are in consistance with the available literature will be analysed and discussed in detail. The urokinetogram opens new possibilities to get insights into the physiology of urine transport and is therefore of great interest as an addition to radiologic and urodynamic methods.
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PMID:[New aspects of registration and drug influence of ureteral motility ]. 675 Sep 29