Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.8 (
cholinesterase
)
12,691
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A 46-year-old man after an accidental exposure to organophosphates developed florid
adult respiratory distress syndrome
(
ARDS
). A markedly suppressed level of
pseudocholinesterase
and red blood cell
cholinesterase
with profuse salivation and sweating confirmed the diagnosis of organophosphate poisoning. Within 48 hours, patient developed respiratory distress needing intubation. Despite maximum ventilatory support and positive end-expiratory pressure, hypoxia persisted, Swan Ganz (Baxter Healthcare Inc, Irvine, CA) pressures showed low pulmonary capillary wedge pressure and patient died on the third hospital day. An autopsy confirmed the picture of
ARDS
. Other potential causes of
ARDS
were excluded. Although rare, organophosphate poisoning should be added to the list of toxins causing
ARDS
.
...
PMID:Adult respiratory distress syndrome from organophosphate poisoning. 198 45
Among the insecticides, organophosphorous compounds are the agents most involved in deliberate and involuntary intoxications. The toxic effect is mainly due to the inhibition of
cholinesterase
at the cholinergic synapses. Two cases of severe involuntary intoxication are described which were characterized by the development of
ARDS
.
...
PMID:[Severe poisoning with the organophosphorus insecticide thionazine--2 cases with the development of adult respiratory distress syndrome (ARDS)]. 357 50
