Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.79 (hormone-sensitive lipase)
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Human Gene/Protein
usp11 13.8
CGI-49 13.8
hormone-sensitive lipase 13.8
protein kinase C alpha type 12.8
long-chain acyl-CoA synthetase 5 12.8
wingless-type MMTV integration site family, member 10B 12.8
small nuclear ribonucleoprotein polypeptide A 12.3
adipose triglyceride lipase 12.1
myosin-Ic 11.8
OXSM 11.8
HLAL 11.8
Hormone-sensitive lipase 11.7
carboxylesterase 3 11.6
N-acylsphingosine amidohydrolase 1 11.5
peroxisome proliferator-activated receptor gamma 1 11.5
LGALS12 11.5
acyl-CoA thioesterase 1 11.5
LPAAT-alpha 11.5
phosphodiesterase 3B 11.5
Aquaporin-7 11.4
perilipin 11.3
HSL1 11.1
KIAA1363 11.1
GS2 protein 11.0
AGPAT6 11.0
lipid storage droplet protein 5 11.0
arylacetamide deacetylase 10.8
G0S2 10.8
ADPN 10.7
S3-12 10.6
G0S2 protein 10.5
elongation of very long chain fatty acids protein 10.5
aquaporin 7 10.5
1-acylglycerol-3-phosphate O-acyltransferase 2 10.4
G protein-coupled receptor 109A 10.4
Galectin-12 10.4
Upstream transcription factor 1 10.3
acyl-CoA synthetase short-chain family member 2 10.1
PON2 protein 10.1
AdPLA 10.1
PAO-1 10.1
SCTR 10.0
ARFRP1 10.0
HHL 10.0
mucin 3 10.0
TLR5 protein 9.9
HSJ1 9.9
GPAT 9.9
CPT1 9.9
DCS 9.9
paraoxonase 2 9.9
TMEM26 9.8
TIP47 9.8
PDE3B 9.8
carnitine palmitoyltransferase 1 9.8
triacylglycerol hydrolase 9.8
fatty acid transport protein 1 9.8
PRKAG1 9.8
CIDEA 9.7
SLC27A2 9.7
CA VB 9.7
ETF-QO 9.6
Adipose differentiation-related protein 9.6
adipose differentiation-related protein 9.6
AAMP 9.5
ACSF3 9.5
TB7 9.5
Diacylglycerol lipase 9.4
RAB14 9.4
LPL 9.3
preadipocyte factor 9.3
HSD17B8 9.3
cyclin I 9.3
DHTKD1 9.3
BTN 9.3
monoacylglycerol lipase 9.2
steroid dehydrogenase-like protein 9.2
Lipin-1 9.2
ABHD11 9.2
FABP4 9.2
more...
Disease
MMDFS 13.8
AHL 10.9
Jordan's anomaly 10.7
Chronic arthritis 8.1
FAS 7.8
Epithelioma 7.8
gum disease 7.3
Androgen deficiency 7.2
GS2 7.2
Splenic marginal zone lymphoma 7.2
Simpson-Golabi-Behmel syndrome 7.0
Familial combined hyperlipidemia 6.7
Cancer cachexia 6.6
Estrogen deficiency 6.5
SCD 6.5
vibriosis 6.4
EPS 6.3
PAPA 6.2
EPS 6.1
Pseudomonas infection 6.0
choline deficiency 6.0
GHD 5.8
ACS1 5.7
fetal macrosomia 5.5
Liposarcoma 5.5
generalized lipodystrophy 5.5
SDA 5.4
abdominal obesity 5.4
fatty liver 5.4
lipodystrophy 5.3
splenic marginal zone lymphoma 5.3
obesity 5.2
Brucella suis 5.2
MDI 5.1
CSE 5.0
Brucella melitensis 5.0
FPP 5.0
ketosis 4.9
PDE 4.8
alcoholic fatty liver 4.8
glucose intolerance 4.8
FHA 4.8
hypercortisolemia 4.8
crown gall 4.8
LDLR 4.7
PME 4.7
ovarian dysfunction 4.7
Nonalcoholic fatty liver 4.7
McArdle's disease 4.6
hyperlipidemia 4.6
hyperinsulinemia 4.6
MCD 4.6
metabolic disorder 4.6
dyslipidemia 4.5
CCL 4.5
OPA1 4.5
phyllodes tumor 4.4
ichthyosis 4.3
lipoatrophy 4.3
lipidosis 4.3
hyperphagia 4.3
lipid disorder 4.2
NPH 4.1
DM2 4.1
Lip 4.1
liposarcoma 4.1
Reye's syndrome 4.1
Yersinia 4.1
FBS 4.0
Chronic hepatitis C 4.0
hyperosmolality 4.0
diabetic ketoacidosis 4.0
epithelioma 4.0
metabolic syndrome 4.0
LMS 4.0
ichthyosis 3.9
atherosclerotic cardiovascular disease 3.9
cystic fibrosis 3.9
Testes 3.9
legionellosis 3.9
more...
Symptom
twitching 5.7
cachexia 5.2
ketonuria 4.7
starvation 3.9
microbial colonization 3.8
overweight 3.0
acute stress 2.7
lethargy 1.4
anorexia 1.1
collapse 0.6
insomnia 0.5
agitation 0.3
fatigue 0.2
exhaustion 0.1
hypothermia -0.2
weakness -1.4
diarrhea -2.0
pain -4.2
Drug
Masoprocol 11.3
Masoprocol 11.0
Homoserine Lactone 10.8
Alprenolol 7.5
Sesamol 7.0
Protamine sulfate 6.9
Vinpocetine 6.6
DFP 6.6
Carbenoxolone 6.3
Orlistat 6.3
Rosiglitazone 6.2
Glycerol 6.1
Rimonabant 5.5
Tannic acid 5.3
Bosentan 5.1
Bosentan 5.1
Liraglutide 5.1
Papaverine 5.0
Growth hormone 4.9
Growth hormone 4.9
Salicylate 4.7
linolenate 4.6
Azithromycin 4.6
CCL 4.5
Secretin 4.3
balanced salt solution 4.3
AGG 4.2
Forskolin 4.1
DEX 4.0
Monensin 3.9
Capsicum 3.7
DPA 3.5
FeCl3 3.4
Ringer's solution 3.4
EPA 3.4
Nephron 3.3
Vitamin A 3.3
BH4 3.3
VCR 3.2
Kenyan 3.1
Glucagon 3.0
Fructose 3.0
Theophylline 2.9
ADR 2.8
ACT 2.8
Estrogens 2.7
EE2 2.5
FAD 2.4
ETA 2.4
ALA 2.4
CTX 2.4
CTX 2.4
ADM 2.2
CTX 2.1
Retinoic acid 2.1
caffeine 2.0
niacin 2.0
lactose 1.8
Portal 1.8
Adriamycin 1.7
Ethanol 1.6
citric acid 1.6
MAP 1.5
ICI 1.5
CAM 1.3
Bifidobacterium 1.3
SiO2 1.3
ROS 1.2
DNase I 0.8
ABC 0.7
Leaf 0.4
NADH 0.4
ZnO 0.1
lysine 0.0
Monit -0.3
ascorbate -0.6
IFN-gamma -1.0
Dermatol -3.2
Cardiovasc -3.8
Enzyme
hormone-sensitive lipase 13.8
PvdQ 11.6
LasR 11.1
AiiA 10.9
lactonase 9.7
erythritol kinase 9.7
PurK 9.7
cholesterol esterase 9.6
monoacylglycerol lipase 9.2
LPL 9.2
lipoprotein lipase 8.8
retinyl ester hydrolase 8.5
long-chain acyl-coenzyme A dehydrogenase 8.5
acetyl-CoA carboxylase 8.3
1-acylglycerol-3-phosphate O-acyltransferase 8.2
acylase 8.1
electron transfer flavoprotein dehydrogenase 8.1
diacylglycerol acyltransferase 8.1
D-dopachrome tautomerase 7.8
lipase 7.8
glycogenin 7.7
malonyl-CoA decarboxylase 7.6
LipB 7.6
glycerophosphate acyltransferase 7.6
CPT 7.5
NADPH:quinone oxidoreductase 7.5
fatty acid elongase 7.4
beta-ketoacyl reductase 7.4
glycerol-3-phosphate dehydrogenase 7.3
glycerol-3-phosphate dehydrogenase 7.3
zeaxanthin epoxidase 7.2
phospholipid methyltransferase 7.2
acetolactate decarboxylase 7.2
acyl-CoA synthetase 7.1
phosphatidate phosphatase 7.1
acyl-CoA synthetase 7.1
acyl-CoA oxidase 7.1
CPT 7.1
CPT 6.9
AMP-activated protein kinase 6.7
BAT 6.7
AMPK 6.7
LipA 6.6
AMP-activated kinase 6.6
AMPK 6.5
carboxylesterase 6.5
enoyl-ACP reductase 6.4
enoyl-ACP reductase 6.4
PDO 6.4
PDK1 6.2
6-phosphogluconate dehydrogenase 6.2
6-phosphogluconate dehydrogenase 6.2
acetylesterase 6.1
arylamine N-acetyltransferase 6.1
phosphorylase kinase 6.0
3-hydroxyacyl-CoA dehydrogenase 6.0
paraoxonase 6.0
guanase 6.0
estrogen sulfotransferase 5.9
paraoxonase 5.9
glycerol kinase 5.9
phosphoenolpyruvate carboxykinase 5.9
cholesterol acyltransferase 5.8
acyl-CoA dehydrogenase 5.8
phosphoenolpyruvate carboxykinase 5.8
phosphoenolpyruvate carboxykinase 5.8
tannase 5.8
deaminase 5.8
elastase 5.7
3-hydroxy-3-methylglutaryl-CoA reductase 5.7
cytochrome P-450scc 5.7
iodothyronine 5'-deiodinase 5.7
acyl-CoA dehydrogenase 5.7
LuxS 5.6
succinic semialdehyde dehydrogenase 5.6
penicillin acylase 5.6
protein kinase 5.5
CYP7A1 5.5
tryptophanase 5.4
FPS 5.4
more...
Compound
OOHL 13.3
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
Ginkgolide C 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
XCT 790 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
3-phenylbutanoic acid 11.8
1-heptadecanol 11.5
homoserine 11.3
homoserine 11.3
homoserine 11.3
3-phenylbutanoic acid 11.0
3-phenylbutanoic acid 11.0
Ginkgolide C 10.9
Sinensetin 10.0
JP-2 9.5
2,4,5-trimethoxybenzaldehyde 9.5
MEDA 9.5
Cholesteryl oleate 9.3
Cholesteryl oleate 9.2
Morusin 8.9
Medicarpin 8.8
Raspberry ketone 8.8
2-dodecenoic acid 8.7
2,5-piperazinedione 8.7
vinyl laurate 8.6
Laminariaceae 8.5
Pinoresinol 8.5
Phenyllactic acid 8.3
1-octacosanol 8.3
hexadecanedioic acid 8.2
Pyocyanin 8.2
4-methoxycinnamic acid 8.1
Phosphoserine 7.9
Diosmetin 7.9
Evodiamine 7.8
Evodiamine 7.7
Bilobalide 7.6
Zingerone 7.6
FFA 7.5
heptyl 7.5
heptyl 7.5
IAA-94 7.5
2,3-pentanedione 7.5
PTO 7.3
Triolein 7.3
Oil Red O 7.2
TLA 7.1
CPT 7.1
DFD 7.1
Sesamol 7.0
CPT 6.9
OPDA 6.9
Oil Red O 6.9
phenazine 6.9
Bifenthrin 6.8
A101 6.7
M 3 6.7
HfO2 6.5
Glycyrrhetinic acid 6.4
DPS 6.4
Conjugated linoleic acid 6.4
glycerol 6.4
Piceatannol 6.3
Fucoxanthin 6.3
Genipin 6.2
more...