Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.79 (hormone-sensitive lipase)
 2,163 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A multivariate analysis was done for the observed variations of lipids, lipoproteins, glycoproteins, and other laboratory tests occurring after myocardial infarction. The origin of plasma triglyceride increase and VLDL-protein reduction is discussed in relation with modified enzyme activities (hormone-sensitive lipase, lipoprotein-lipase, LCAT). The relations between HDL and lipids, glucose, area are analyzed. Changes in VLDL are opposite in direction from the changes in HDL. Delayed significant increase in haptoglobin and alpha 1-antitrypsin exist with a tendency to an increase in C3 and IgM. Various associations link lipoprotein constituents to alpha 1-antitrypsin, IgM, witnesses of the development of an inflammatory process. Recent introduction of apoprotein determinations will bring new outlook on changes accompanying myocardial infarction.
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PMID:Relationship between plasma lipids, lipoproteins and other laboratory tests during the course of acute myocardial infarction. 660 91

Berberine (BBR), an isoquinoline alkaloid, has a wide range of pharmacological effects, yet its exact mechanism is unknown. In order to understand the anti-adipogenic effect of BBR, we studied the change of expression of several adipogenic enzymes of 3T3-L1 cells by BBR treatment. First, we measured the change of leptin and glycerol in the medium of 3T3-L1 cells treated with 1 micrometer, 5 micrometer and 10 micrometer concentrations of BBR. We also measured the changes of adipogenic and lipolytic factors of 3T3-L1. In 3T3-L1 cells, both leptin and adipogenic factors (SREBP-1c, C/EBP-alpha, PPAR-gamma, fatty acid synthase, acetyl-CoA carboxylase, acyl-CoA synthase and lipoprotein lipase) were reduced by BBR treatment. Glycerol secretion was increased, whereas expression of lipolytic enzymes (hormone-sensitive lipase and perilipin) mRNA was slightly decreased. Next, we measured the change of inflammation markers of 3T3-L1 cells by BBR treatment. This resulted in the down-regulation of mRNA level of inflammation markers such as TNF-alpha, IL-6, C- reactive protein and haptoglobin. Taken together, our data shows that BBR has both anti-adipogenic and anti-inflammatory effects on 3T3-L1 adipocytes, and the anti-adipogenic effect seems to be due to the down-regulation of adipogenic enzymes and transcription factors.
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PMID:Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. 1720 35