Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.7 (acetylcholinesterase)
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Human Gene/Protein
acetylcholinesterase isoform E4-E6 precursor 10.1
downstream of tyrosine kinase 7 10.1
acetylcholinesterase 10.0
butyrylcholinesterase 9.6
COLQ 9.4
Cholinesterase 9.3
CUTA 9.1
RING finger protein 121 9.1
X-linked neuroligin 4 9.1
RIC8 9.1
major facilitator superfamily domain containing 1 9.1
AChE 9.1
ACHE 9.0
pseudocholinesterase 8.8
CHE1 8.8
neuropathy target esterase 8.8
Erythroid transcription factor 8.5
choline acetylase 8.4
TEPP 8.2
macoilin 8.1
Carboxylesterase 8.0
RIC-3 8.0
Choline acetyltransferase 7.9
carboxylesterase 7.9
FAM155A 7.8
glutamate receptor homolog 7.8
ALG14 7.8
choline acetyltransferase 7.8
ADAS 7.5
DCLK3 7.5
NFASC 7.5
Cadherin-8 7.5
PRIMA 7.5
NIMP 7.4
ArhGAP15 7.4
ARHGAP15 7.4
alkaline phosphomonoesterase 7.4
choline transporter 7.4
phospholipase C beta 4 7.3
lipocalin-1 interacting membrane receptor 7.3
acetylcholine receptor epsilon subunit 7.3
RAB11B 7.3
phosphodiesterase 9A 7.3
T. californica 7.3
Mina53 7.2
CTL3 7.1
CHRNB 7.1
GDNF family receptor alpha 2 7.1
APH1A 7.0
uridine phosphorylase 1 7.0
alpha 4(IV) collagen 7.0
Wol 7.0
DOK7 6.9
MuSK 6.9
pancreatic cholesterol esterase 6.9
rapsyn 6.9
CHRNA 6.8
PSSC 6.8
goa 6.8
NTE 6.8
CHRNE 6.8
Succinic dehydrogenase 6.8
vesicular acetylcholine transporter 6.7
SLC10A4 6.7
arylesterase 6.7
phosphorylase, glycogen 6.7
OTOG 6.7
laminin alpha 5 6.7
tryptase beta I 6.7
QN1 6.7
limbic system-associated membrane protein 6.6
synapsin IIa 6.6
paraoxonase 6.6
gamma adaptin 6.5
MADA 6.5
alpha 7 neuronal nicotinic acetylcholine receptor 6.5
ChAT 6.4
Ligatin 6.4
Lutheran glycoprotein 6.4
ASB1 6.4
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Disease
Impairment of attention 10.1
Specific disorders of sleep 10.1
Cholinergic crisis 9.8
Hyperganglionosis 9.5
Acute cholestatic hepatitis 9.1
Berdon's syndrome 9.1
Thyrotoxic myopathy 9.1
Pseudocholinesterase deficiency 8.5
Prolonged neuromuscular block 8.5
Chromodacryorrhea 8.5
OI7 8.5
Idiopathic megacolon 8.5
BD syndrome 8.5
Sundowning 8.3
Congenital Myasthenic Syndromes 8.3
NID B 8.1
urination disorder 8.1
Transient neonatal myasthenia gravis 8.1
Intercurrent disease 7.8
Congenital myasthenia 7.8
Dementia in Parkinson's disease 7.7
Bronchopulmonary infection 7.5
Alzheimer's disease with early onset 7.3
Neuronal intestinal dysplasia 7.3
Distal spinal muscular atrophy 7.3
Transient amnesia 7.1
vascular hypoxia 7.1
GSM1 7.1
Pisa syndrome 7.1
FIF 7.1
BPSD 7.1
blepharoclonus 7.0
Macronodular cirrhosis 6.8
Upbeat nystagmus 6.8
Gulf War Syndrome 6.5
Subcortical vascular dementia 6.5
Meige's disease 6.5
Guanidinoacetate methyltransferase deficiency 6.4
Myasthenic crisis 6.4
Acute glaucoma 6.4
disturbed memory 6.4
Enzyme inhibition 6.4
PA-JEB 6.3
CLAM 6.3
FRA16A 6.3
Ocular myasthenia 6.3
Vascular dementia 6.3
alcoholic dementia 6.3
prodromal schizophrenia 6.2
CDA III 6.2
Chinese restaurant syndrome 6.1
Anaphylactoid reaction 6.1
Bonnier 6.1
ABO hemolytic disease of the newborn 6.1
myasthenia 6.1
Total colonic aganglionosis 6.0
hyperprolinemia 5.9
Sleep attacks 5.9
memory impairment 5.8
bronchorrhea 5.8
Cognitive deterioration 5.8
OBX 5.8
Stereotypic behavior 5.7
parasympathomimetic 5.7
Dementia with Lewy bodies 5.6
Junctional epidermolysis bullosa 5.6
Aluminum intoxication 5.6
Ogilvie's syndrome 5.6
senile dementia 5.5
MNGIE 5.5
Alzheimer's disease 5.5
Diabetic encephalopathy 5.5
AD11 5.4
myasthenia gravis 5.4
Neuromuscular blockade 5.4
cognitive deficit 5.3
Piscirickettsiosis 5.3
FHM2 5.3
thymic neoplasm 5.1
Frohlich 5.1
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Symptom
Slight fever 10.1
Moist rales 9.1
ACHE 8.6
Antecollis 7.3
Death rattle 7.1
Increased libido 6.7
Cramping 6.5
Local swelling 6.4
Behavioral symptoms 5.8
loss of equilibrium 5.6
visual hallucination 5.5
memory loss 5.4
redness of the eyes 5.4
urological problem 5.3
fasciculation 4.8
Reticulocytosis 4.5
chronic constipation 4.1
leg cramps 3.9
apathy 3.8
abiotrophy 3.8
Deafferentation 3.7
frequent urination 3.7
Excitable 3.7
incoordination 3.5
Positive and Negative Symptoms 3.5
giddiness 3.5
giddiness 3.5
Decreased activity 3.4
nerve pain 3.4
muscle cramps 3.3
twitching 3.3
rundown 3.2
blurred vision 3.0
agitation 2.9
startle reaction 2.9
motor symptom 2.8
weakness 2.8
skin irritation 2.8
forgetfulness 2.7
lightheadedness 2.7
hypalgesia 2.7
abdominal cramps 2.7
adipsia 2.6
prostration 2.6
constipation 2.5
Gastrointestinal symptoms 2.5
Extrapyramidal symptoms 2.5
aphagia 2.5
despair 2.5
Involuntary Movement 2.5
hypothermia 2.5
tremor 2.4
tonic seizure 2.4
inanition 2.3
loss of balance 2.3
dizziness 2.3
seizures 2.3
bradykinesia 2.3
Multimorbidity 2.2
rhinorrhea 2.1
chest tightness 2.1
athetosis 2.1
ataxia 2.1
hyperesthesia 2.1
body pain 2.1
personality change 2.0
nausea 2.0
dark urine 2.0
hypoproteinemia 2.0
acute stress 2.0
excessive sweating 2.0
asthenia 1.9
Fluctuation 1.9
Burning 1.9
ophthalmoplegia 1.9
syncope 1.9
functional recovery 1.8
rales 1.8
No adverse effect 1.8
Psychiatric symptoms 1.8
more...
Drug
Protopam Chloride 10.1
Hexafluorenium 10.1
Pralidoxime 9.6
Galanthamine 9.6
Doxacurium chloride 9.5
Distigmine bromide 9.5
Donepezil 9.5
Reminyl 9.3
Aricept 9.3
Galantamine hydrobromide 9.3
Exelon 9.2
Pyridostigmine bromide 9.2
Butyrylthiocholine 9.1
Temefos 9.1
Cognex 9.1
Exelon 9.1
Mestinon 8.8
Phospholine Iodide 8.8
Pyridostigmine bromide 8.6
Nicergolin 8.5
Cardamom oil 8.5
Camphane 8.5
Mivacron 8.3
Velnacrine maleate 8.1
Echothiophate iodide 8.1
DFP 7.9
Haemanthamine 7.8
Mivacron 7.8
Serrapeptase 7.8
Namenda 7.8
Tubocurarine chloride 7.5
Edrophonium chloride 7.5
Prostigmin 7.5
Orphenadrine citrate 7.3
Sugammadex sodium 7.3
Disipal 7.3
Brij 96 7.3
Azilect 7.1
Zenarestat 7.1
Physostigmine salicylate 7.0
Eserine sulfate 7.0
SR 57746A 7.0
EDR 6.9
THA 6.8
Parbendazole 6.8
Lemon oil 6.8
Methscopolamine 6.7
Scopolamine hydrobromide 6.5
Dexetimide 6.5
Atracurium besylate 6.5
Scopolamine 6.5
Bisacodyl 6.5
Gluthathione 6.4
2,4,6-Tribromophenol 6.3
DMAA 6.3
Gallamine 6.2
Quinidine sulfate 6.1
Kifunensine 6.1
Diphenidol 6.1
Clorsulon 6.1
Sulfamide 6.0
Aluminum chloride 5.9
Propanidid 5.9
Atropine 5.9
Arduan 5.8
Tropicamide 5.8
Eucalyptus oil 5.7
1,8-Cineole 5.7
Atropine sulfate 5.6
Eucerin 5.6
Lipoic Acid 5.6
Arfonad 5.6
Imidan 5.5
Alendronate sodium 5.5
Tubocurarine 5.5
Phenoxymethylpenicillin 5.5
Cevimeline 5.5
Fluspirilene 5.5
Rokitamycin 5.4
Propentofylline 5.4
more...
Enzyme
acetylcholinesterase 10.1
EC 1.1.1.7 10.1
cholinesterase 9.9
zingipain 8.5
choline oxidase 8.4
aspirin esterase 8.3
DFPase 8.1
atropine esterase 8.0
choline acetyltransferase 7.8
carboxyamidase 7.8
uronolactonase 7.8
AAA-1 7.7
3'(2'),5'-bisphosphate nucleotidase 7.4
carboxylesterase 7.3
neuropathy target esterase 6.9
paraoxonase 6.6
paraoxonase 6.5
GPI-PLD 5.9
LGT 5.9
2',3'-cyclic nucleotide phosphohydrolase 5.7
EC 1.1.1.38 5.7
Dol-P phosphatase 5.7
dienelactone hydrolase 5.6
phosphatidylinositol phospholipase C 5.5
acetylesterase 5.4
YdcW 5.4
oxaloacetate acetylhydrolase 5.4
NADPH-diaphorase 5.3
adenosine nucleosidase 5.3
acetyl-CoA hydrolase 5.3
beta-secretase 5.1
monoamine oxidase 5.1
diaphorase 5.1
succinic dehydrogenase 5.0
esterase D 5.0
PAM 4.9
5'-nucleotidase 4.9
cholesterol esterase 4.9
octopine dehydrogenase 4.9
prolyl endopeptidase 4.8
GPI-specific phospholipase C 4.8
nucleotidase 4.6
monoacylglycerol lipase 4.6
prolinase 4.6
CBPP 4.5
choline kinase 4.5
dopamine beta-hydroxylase 4.5
glutamate decarboxylase 4.5
glutathione S-transferase 4.5
delta-aminolevulinic acid dehydratase 4.5
leucine aminopeptidase 4.4
diaphorase 4.4
CNPase 4.4
trimetaphosphatase 4.4
tyrosinase 4.4
glutamic dehydrogenase 4.3
serum carnosinase 4.3
UDP-N-acetylglucosamine pyrophosphorylase 4.3
glutathione reductase 4.3
Mg2+-ATPase 4.3
NSY 4.3
histidase 4.3
glutathione peroxidase 4.3
GP-I 4.2
carnitine acetyltransferase 4.2
dolichol kinase 4.2
catalase 4.2
histamine N-methyltransferase 4.2
pantothenate synthetase 4.2
PI-PLC 4.1
catechol O-methyltransferase 4.1
tyrosine hydroxylase 4.1
lactate dehydrogenase 4.0
succinate dehydrogenase 4.0
AAE 4.0
sorbitol dehydrogenase 4.0
NQO1 4.0
superoxide dismutase 3.9
leishmanolysin 3.9
beta-hydroxybutyrate dehydrogenase 3.9
more...
Compound
C28H34N2O6 10.1
Diphenidol hydrochloride 10.1
Isoxathion 10.1
C13H18N2O2 10.1
Cernuine 10.1
C13H18N2O2 10.1
Methantheline 10.1
C13H18N2O2 10.1
Tetrabromophthalic anhydride 10.1
C13H18N2O2 10.1
Fyrol 6 10.1
propylboronic acid 10.1
C28H34N2O6 10.1
C13H18N2O2 10.1
2-Amino-4-phenylthiazole 10.1
C13H18N2O2 10.1
C13H18N2O2 10.1
Acanthoside B 10.1
4-amino-3-hydroxy-1-naphthalenesulfonic acid 10.1
1,4-bis(phenylsulfonyl)piperazine 10.1
4-amino-2-((diethylamino)methyl)phenol 10.1
C13H18N2O2 10.1
Belladine 10.1
Fawcettimine 10.1
C13H18N2O2 10.1
Bis(trichloromethyl) sulfone 10.1
C13H18N2O2 10.1
C13H18N2O2 10.1
C13H18N2O2 10.1
(4-bromophenyl)acetic acid 10.1
C13H18N2O2 10.1
C13H18N2O2 10.1
C13H18N2O2 10.1
Isoterchebin 10.1
C13H18N2O2 10.1
C13H18N2O2 10.1
Verticine 10.1
C13H18N2O2 10.1
4-methyl-1-(propylsulfonyl)piperidine 10.1
C28H34N2O6 10.1
Acetylcaranine 10.1
F 2268 10.1
C13H18N2O2 10.1
C13H18N2O2 10.1
Acetylthiocholine iodide 9.9
Ambenonium 9.7
OMPA 9.7
Pralidoxime 9.6
Echothiophate 9.6
2-butenediamide 9.5
Lycodine 9.5
5,6-dichloronicotinic acid 9.5
dimethylsulfamoyl chloride 9.5
Piperazine adipate 9.5
TMB-4 9.5
Rivastigmine 9.3
Bromophos 9.3
Pyridostigmine 9.3
galanthamine 9.3
ethyl methylcarbamate 9.3
Tacrine 9.2
C13H18N2O2 9.1
diethyl hydrogen phosphate 9.1
diethyl hydrogen phosphate 9.1
phosphorofluoridic acid 9.1
Nicoline 9.1
Dipterocarpol 9.1
Annotine 9.1
gamma-Fagarine 9.1
diethyl hydrogen phosphate 9.1
phosphorofluoridic acid 9.1
Butyrylcholine iodide 9.1
Pretazettine 9.1
C14H14O2 9.1
diethyl hydrogen phosphate 9.1
C13H18N2O2 9.1
C13H10N2O6 9.1
Butyl disulfide 9.1
AB 100 9.1
C15H11NO3 9.1
more...